INT352870

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IKBKAP) nucleolus (IKBKAP) nucleus (IKBKAP)
protein complex assembly (IKBKAP) DNA binding (IKBKAP) cytoplasm (IKBKAP)
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 225 92.72 High High
Neurodegenerative Disease 3 86.52 High High
Toxicity 15 78.80 Quite High
Neuromuscular Disease 3 72.00 Quite High
Apoptosis 3 70.96 Quite High
Spinal Muscular Atrophy 3 70.16 Quite High
Cognitive Disorder 21 66.08 Quite High
Attention Deficit Hyperactivity Disorder 6 61.72 Quite High
Dementia 12 57.36 Quite High
Aging 3 14.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rather PS acted by increasing levels of transcription of this gene; increased levels of mRNA led to elevation of the level of the normal IKAP protein.
Positive_regulation (led) of Positive_regulation (elevation) of IKAP protein
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.94 Pain Relevance 0
In the heterozygous cell line, PS treatment induced a slight increase in IKAP mRNA (data not shown).
Positive_regulation (induced) of Positive_regulation (increase) of IKAP mRNA
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.17 Pain Relevance 0
The divergence of our altered genes due to PS treatment from those reported in the literature in cells without IKAP indicate the unique mechanism of action that results in the PS-induced increase in IKAP levels.
Positive_regulation (induced) of Positive_regulation (increase) of IKAP
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.43 Pain Relevance 0

General Comments

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