INT352893

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PTGDS, TP53) cytoplasm (PTGDS, TP53) cell differentiation (TP53)
nucleoplasm (TP53) mitochondrion (TP53) transport (PTGDS)
Anatomy Link Frequency
chondrocyte 1
PTGDS (Homo sapiens)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 3 93.04 High High
Osteoarthritis 64 86.72 High High
Mechanotransduction 1 16.64 Low Low
Inflammation 9 11.76 Low Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 100.00 Very High Very High Very High
Arthritis 3 93.04 High High
Osteoarthritis 71 86.72 High High
Stress 19 74.64 Quite High
Osteogenic Sarcomas 1 72.80 Quite High
Death 7 57.60 Quite High
Cancer 1 26.60 Quite Low
INFLAMMATION 11 11.76 Low Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently demonstrated that PGD2 and/or its metabolite 15d-PGJ2 mediate chondrocyte apoptosis via PKA-dependent regulation of p53 phosrphorylation [9].
PGD2 Regulation (regulation) of p53 in chondrocyte associated with apoptosis
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.02 Pain Relevance 0.26

General Comments

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