INT3529

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Context Info
Confidence 0.52
First Reported 1976
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.40
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GOT1) small molecule metabolic process (GOT1) biosynthetic process (GOT1)
carbohydrate metabolic process (GOT1) cellular nitrogen compound metabolic process (GOT1) lysosome (GOT1)
Anatomy Link Frequency
blood 2
hepatocytes 1
GOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 1 100.00 Very High Very High Very High
fibrosis 1 97.60 Very High Very High Very High
Paresthesia 2 96.88 Very High Very High Very High
headache 3 94.80 High High
agonist 4 93.28 High High
methotrexate 15 88.56 High High
Parenteral administration 2 79.28 Quite High
Bile 3 78.72 Quite High
antagonist 1 76.76 Quite High
Analgesic 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Obesity 5 98.54 Very High Very High Very High
Leukopenia 3 97.84 Very High Very High Very High
Fibrosis 1 97.60 Very High Very High Very High
Toxicity 8 96.88 Very High Very High Very High
Dysesthesia 3 96.88 Very High Very High Very High
Pharyngitis 2 96.20 Very High Very High Very High
Cardiovascular Disorder Under Development 1 94.96 High High
Headache 3 94.80 High High
Heartburn 2 94.40 High High
Vomiting 7 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activities of blood cholinesterase, glutamic oxalacetic transaminase, glutamic pyruvic transaminase, as well as hematocrit values, heart rate, and blood pressure were not affected.
Neg (not) Regulation (affected) of transaminase in blood
1) Confidence 0.52 Published 1976 Journal Arch. Toxicol. Section Abstract Doc Link 788681 Disease Relevance 0.57 Pain Relevance 0.18
Activities of blood cholinesterase, glutamic oxalacetic transaminase, glutamic pyruvic transaminase, as well as hematocrit values, heart rate, and blood pressure were not affected.
Neg (not) Regulation (affected) of transaminase in blood
2) Confidence 0.38 Published 1976 Journal Arch. Toxicol. Section Abstract Doc Link 788681 Disease Relevance 0.56 Pain Relevance 0.18
By day 22, our patient's transaminase and bilirubin values were decreased and his clinical condition improved.
Regulation (values) of transaminase
3) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2978230 Disease Relevance 0.42 Pain Relevance 0.12
There was an increase in serum glutamic pyruvic transaminase (SGPT) and serum alkaline phosphatase (SAP) level with the crude extract but stagninol showed no significant changes of serum glutamic oxaloacetic transaminase (SGOT), SGPT and SAP level.
Neg (no) Regulation (changes) of serum glutamic oxaloacetic transaminase
4) Confidence 0.01 Published 1997 Journal Pharmazie Section Abstract Doc Link 9260269 Disease Relevance 0.23 Pain Relevance 0.15
Increase in transaminase values were registered in 8 cases (36%) (2 cases with grade III).
Regulation (values) of transaminase
5) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.44 Pain Relevance 0.04
Furthermore, the leucine recognition site that regulates TOR signaling in adipocytes appears to be different from the following: (1) a leucine receptor that regulates macroautophagy in liver, (2) a leucine recognition site that regulates TOR signaling in H4IIE hepatocytes, (3) leucyl tRNA or leucyl tRNA synthetase, (4) the gabapentin-sensitive leucine transaminase, or (5) the system L-amino acid transporter.
Regulation (regulates) of transaminase in hepatocytes associated with obesity and gabapentin
6) Confidence 0.01 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10723090 Disease Relevance 0.17 Pain Relevance 0.33

General Comments

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