INT352914

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HINFP) histone binding (HINFP) nucleolus (HINFP)
nucleus (HINFP) intracellular (HINFP) enzyme binding (HINFP)
Anatomy Link Frequency
fibroblasts 2
HINFP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 64 77.60 Quite High
Arthritis 3 53.20 Quite High
Inflammation 9 45.68 Quite Low
cytokine 3 6.12 Low Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 1 95.40 Very High Very High Very High
Apoptosis 11 77.72 Quite High
Osteoarthritis 71 77.60 Quite High
Cancer 1 60.52 Quite High
Arthritis 3 53.20 Quite High
INFLAMMATION 11 45.68 Quite Low
Leukemia 1 7.92 Low Low
Stress 19 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of histone gene expression has been detected after DNA damage induced by ionizing radiation in different cells such as human fibroblasts and osteosarcoma [41].
Negative_regulation (Downregulation) of Gene_expression (expression) of histone gene in fibroblasts associated with osteogenic sarcomas
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.56 Pain Relevance 0.16

General Comments

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