INT352920

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chondrocytes 2
polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 96.28 Very High Very High Very High
Osteoarthritis 64 95.16 Very High Very High Very High
rheumatoid arthritis 3 82.48 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 95.92 Very High Very High Very High
Osteoarthritis 71 95.16 Very High Very High Very High
Death 7 92.32 High High
Adhesions 2 91.48 High High
Rheumatoid Arthritis 3 82.48 Quite High
Apoptosis 11 6.16 Low Low
Stress 19 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although prolonged application of fluid shear increased the mRNA synthesis of TCDD-inducible poly(ADP-ribose) polymerase (PARP-1) in human T/C-28a2 chondrocytes (Table 1), a recent microarray study reported this gene to be down-regulated in OA chondrocytes relative to normal controls [15].
Positive_regulation (increased) of Transcription (synthesis) of polymerase in chondrocytes associated with osteoarthritis
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.85 Pain Relevance 0.33

General Comments

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