INT353010

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GJA8, TNF) signal transduction (TNF) extracellular space (TNF)
transport (GJA8) extracellular region (TNF) intracellular (TNF)
GJA8 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Etanercept 12 95.08 Very High Very High Very High
Infliximab 130 94.76 High High
Adalimumab 66 94.44 High High
Potency 2 53.84 Quite High
corticosteroid 32 47.28 Quite Low
Bioavailability 4 41.76 Quite Low
cytokine 8 30.72 Quite Low
Inflammation 26 5.00 Very Low Very Low Very Low
methotrexate 10 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 96.40 Very High Very High Very High
Disease 196 86.80 High High
Inflammatory Bowel Disease 24 5.00 Very Low Very Low Very Low
INFLAMMATION 22 5.00 Very Low Very Low Very Low
Apoptosis 22 5.00 Very Low Very Low Very Low
Urinary Tract Infection 8 5.00 Very Low Very Low Very Low
Abdominal Pain 8 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Abscess 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, it is not time to make such a judgment with CZP too, or other new anti-TNF-alfa agents.
CZP Binding (judgment) of TNF
1) Confidence 0.02 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012434 Disease Relevance 0.24 Pain Relevance 0.05
Since it lacks the Fc portion of the antibody, CZP only exerts its activity through binding to soluble and membrane-bound TNF-alfa, and cannot bind to cell-surface receptors for antibodies; consequently, complement fixation and cell lysis do not occur.
CZP Binding (binding) of TNF
2) Confidence 0.02 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012434 Disease Relevance 0 Pain Relevance 0.29

General Comments

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