INT35307

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 2005
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.21
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adk) nucleus (Adk) kinase activity (Adk)
Anatomy Link Frequency
spinal cord 1
platelet 1
Adk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 154 100.00 Very High Very High Very High
Antinociceptive 15 99.98 Very High Very High Very High
Endep 11 99.84 Very High Very High Very High
Spinal cord 4 99.76 Very High Very High Very High
Pain 18 99.46 Very High Very High Very High
Neurotransmitter 2 99.44 Very High Very High Very High
Inflammation 16 99.20 Very High Very High Very High
Paracetamol 4 98.82 Very High Very High Very High
Thermal hyperalgesia 4 97.32 Very High Very High Very High
Peripheral nervous system 3 91.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.20 Very High Very High Very High
Injury 8 98.52 Very High Very High Very High
Hyperalgesia 4 97.32 Very High Very High Very High
Nociception 3 96.92 Very High Very High Very High
Glioma 1 94.36 High High
Stress 3 93.72 High High
Pain 10 92.84 High High
Convulsion 2 92.52 High High
Pressure And Volume Under Development 2 81.68 Quite High
Epilepsy 7 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenosine kinase (AK) is the primary metabolic enzyme regulating intra- and extracellular concentrations of ADO.
Regulation (regulating) of AK associated with adenocard
1) Confidence 0.35 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 15638777 Disease Relevance 0.34 Pain Relevance 0.54
Adenosine kinase (AK) is the primary metabolic enzyme regulating intra- and extracellular concentrations of ADO.
Regulation (regulating) of Adenosine kinase associated with adenocard
2) Confidence 0.35 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 15638777 Disease Relevance 0.34 Pain Relevance 0.54
The possible enhancement of the antinociceptive effects of adenosine kinase inhibitors by an adenosine deaminase inhibitor also was investigated.
Regulation (effects) of adenosine kinase associated with adenocard and antinociceptive
3) Confidence 0.32 Published 1998 Journal Pain Section Abstract Doc Link 9520238 Disease Relevance 0.58 Pain Relevance 0.95
This study examined the ability of an adenosine kinase inhibitor (5'-amino-5'-deoxyadenosine; NH2dAD), an adenosine deaminase inhibitor (2'-deoxycoformycin), and combinations of these agents to produce a peripheral modulation of the pain signal in the low concentration formalin model.
Spec (examined) Regulation (ability) of adenosine kinase associated with pain, adenocard and eae
4) Confidence 0.26 Published 1998 Journal Pain Section Abstract Doc Link 9514563 Disease Relevance 0.09 Pain Relevance 0.41
Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test.
Regulation (effect) of adenosine kinase associated with pain, adenocard and antinociceptive
5) Confidence 0.26 Published 1998 Journal Pain Section Title Doc Link 9514563 Disease Relevance 0.09 Pain Relevance 0.82
The effects of the adenosine kinase inhibitors, 5'-amino-5'-deoxyadenosine (NH2dAD) and iodotubercidin (IOT), and the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF), on adenosine release in a spinal cord superfusion model were studied.
Regulation (effects) of adenosine kinase in spinal cord associated with adenocard and spinal cord
6) Confidence 0.21 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616636 Disease Relevance 0.09 Pain Relevance 0.90
In enzyme assays, amitriptyline had no effect on adenosine kinase or adenosine deaminase activity.
Neg (no) Regulation (effect) of adenosine kinase associated with adenocard and endep
7) Confidence 0.18 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16156010 Disease Relevance 0.09 Pain Relevance 1.25
Adenosine kinase (AK) is a key intracellular enzyme regulating intra- and extracellular concentrations of ADO.
Regulation (regulating) of AK associated with adenocard
8) Confidence 0.12 Published 2004 Journal Curr. Pharm. Des. Section Abstract Doc Link 15078144 Disease Relevance 0.77 Pain Relevance 0.64
Adenosine kinase (AK; EC 2.7.1.20) is the primary metabolic enzyme regulating intra- and extracellular concentrations of ADO.
Regulation (regulating) of AK associated with adenocard
9) Confidence 0.05 Published 2001 Journal CNS Drug Rev Section Abstract Doc Link 11830758 Disease Relevance 0.37 Pain Relevance 0.44
Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra and extracellular concentrations of adenosine (ADO), an endogenous modulator of intercellular signalling that reduces cell excitability during tissue stress and trauma.
Regulation (regulating) of AK associated with stress, adenocard and injury
10) Confidence 0.04 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060695 Disease Relevance 0.19 Pain Relevance 0.32
ADO kinase (AK; EC 2.7.1.20) is the key intracellular enzyme regulating intra- and extracellular ADO concentrations.
Regulation (regulating) of AK associated with adenocard
11) Confidence 0.03 Published 1998 Journal Curr. Pharm. Des. Section Abstract Doc Link 10197052 Disease Relevance 0.26 Pain Relevance 0.54
The in vitro antiaggregating action of paracetamol and ten of its derivatives was studied by observing their action on collagen, adenosine-5 diphosphate (ADP) and arachidonic acid-induced platelet aggregation.
Regulation (action) of adenosine-5 diphosphate in platelet associated with adenocard and paracetamol
12) Confidence 0.01 Published 1988 Journal Thromb. Res. Section Abstract Doc Link 3134743 Disease Relevance 0 Pain Relevance 0.43

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