INT353070

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.66
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADAM17, TNF) intracellular (TNF) extracellular matrix organization (TNF)
cytoplasm (ADAM17) signal transduction (TNF) peptidase activity (ADAM17)
ADAM17 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 61.80 Quite High
Inflammation 11 51.00 Quite High
Infliximab 108 50.00 Quite Low
corticosteroid 13 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 20 97.36 Very High Very High Very High
Inflammatory Bowel Disease 106 97.04 Very High Very High Very High
Disease 70 94.52 High High
Apoptosis 6 70.32 Quite High
INFLAMMATION 10 51.00 Quite High
Cleidocranial Dysplasia 5 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Hemorrhage 4 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the TNF-alfa converting enzyme (TACE), which serves to activate and release TNF from the cell membrane, is specifically increased in colonic biopsies of UC patients as compared to biopsies from patients with CrohnÂ’s disease or healthy individuals (Brynskov et al. 2002).
TACE Positive_regulation (activate) of TNF associated with inflammatory bowel disease and disease
1) Confidence 0.19 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.66 Pain Relevance 0.08

General Comments

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