INT353128

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.95
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) Golgi apparatus (B3GAT1)
plasma membrane (TAC1) carbohydrate metabolic process (B3GAT1) cell-cell signaling (TAC1)
Anatomy Link Frequency
brain 4
TAC1 (Homo sapiens)
B3GAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 10 100.00 Very High Very High Very High
antagonist 66 97.08 Very High Very High Very High
Antiemetics 16 91.44 High High
Serotonin 44 88.56 High High
corticosteroid 24 35.04 Quite Low
dexamethasone 62 20.36 Low Low
Dopamine 8 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 424 99.92 Very High Very High Very High
Cancer 10 94.04 High High
Breast Cancer 6 55.96 Quite High
Clinical Trials And Case Reports 4 54.80 Quite High
Fatigue 8 5.00 Very Low Very Low Very Low
Constipation 8 5.00 Very Low Very Low Very Low
Neutropenia 6 5.00 Very Low Very Low Very Low
Appetite Loss 4 5.00 Very Low Very Low Very Low
Headache 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aprepitant is believed to prevent emesis by blocking the binding of substance P to NK1 receptors in the brain.
Negative_regulation (blocking) of substance P Binding (binding) of NK1 in brain associated with vomiting and substance p
1) Confidence 0.29 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 0.92 Pain Relevance 0.18
Aprepitant is thought to prevent emesis by blocking the binding of substance P to NK1 receptors in the brain (Aguilar et al. 2005; Kris et al. 2005; Viale 2005).
Negative_regulation (blocking) of substance P Binding (binding) of NK1 in brain associated with vomiting and substance p
2) Confidence 0.29 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 1.03 Pain Relevance 0.14

General Comments

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