INT353145

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0.65

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)

CA1 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 86 99.68 rheumatoid arthritis 38 93.76 Osteoarthritis 36 90.32 Inflammation 7 31.04 cINOD 4 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Low Back Pain 85 99.68 Rheumatoid Arthritis 38 93.76 Frailty 38 90.32 Disorder Of Lipid Metabolism 2 57.56 INFLAMMATION 9 31.04 Alpha-1-antitrypsin Deficiency 4 24.68 Disease 24 5.00 Hypercalcemia 11 5.00 Calcification 5 5.00 Hyperplasia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemistry detected CA1 expression in all AS synovial tissues (100%) and yielded high intensity signals.

Negative_regulation (detected) of Gene_expression (expression) of CA1 associated with spinal inflammation

1) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.01 Pain Relevance 0.65

General Comments

This test has worked.