INT353170

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hlf)
Anatomy Link Frequency
hepatocyte 1
Hlf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carbamazepine 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
antiepileptic Drug 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 2 99.48 Very High Very High Very High
Aging 44 91.64 High High
Repression 6 66.20 Quite High
Cancer 2 59.92 Quite High
Disease 8 29.44 Quite Low
Toxicity 14 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Drug-induced Liver Injury 14 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note that the pattern of SCN-controlled clock genes, Dbp, Tef, and Hlf (Hlf's 1.3-fold change did not meet criteria for inclusion in list of DEGs) display a conspicuous correlation with these reports (Figure 5A).
Gene_expression (pattern) of Hlf
1) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.12 Pain Relevance 0
Master circadian regulators Clock and Arntl/Bmal1 (aryl hydrocarbon receptor nuclear translocator-like) control the expression of the PARbZip family of transcription factors which is comprised of three members: Dbp (albumin site D-binding protein), Tef (thyrotroph embryonic factor), and Hlf (hepatocyte leukemia factor).
Gene_expression (expression) of Hlf in hepatocyte associated with leukemia
2) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.32 Pain Relevance 0

General Comments

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