INT35325

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Context Info
Confidence 0.32
First Reported 1988
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 1.13
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
basophils 3
plasma 2
neutrophil 2
mast cells 1
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 7 100.00 Very High Very High Very High
lidocaine 6 100.00 Very High Very High Very High
agonist 15 98.64 Very High Very High Very High
TRP channel 8 94.72 High High
Neurotransmitter 12 92.28 High High
Kinase C 1 88.88 High High
anesthesia 3 80.96 Quite High
potassium channel 6 80.08 Quite High
local anesthetic 1 79.80 Quite High
antagonist 16 72.72 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 6 96.68 Very High Very High Very High
Disease 22 94.56 High High
Neuroblastoma 1 90.48 High High
Pressure And Volume Under Development 26 77.20 Quite High
Malignant Hyperthermia 1 75.00 Quite High
Immunotherapy Of Cancer 1 61.76 Quite High
Death 12 55.44 Quite High
Prostate Cancer 3 54.40 Quite High
INFLAMMATION 111 53.28 Quite High
Altitude Sickness 2 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The identity of the intracellular messenger responsible for the release of these peripheral Ca2+ stores remains unknown.
Regulation (responsible) of Localization (release) of Ca2
1) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Thus our studies have contributed to basic knowledge of regulation of Ca2+ release function.
Regulation (regulation) of Localization (release) of Ca2
2) Confidence 0.27 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9137560 Disease Relevance 0.17 Pain Relevance 0.08
Suppression of 1,4,5-trisphosphate (IP3) formation by 2 microM U73122 (a phospholipase C inhibitor) did not affect 100 microM fluoxetine-induced Ca2+ release.
Neg (not) Regulation (affect) of Localization (release) of Ca2 associated with fluoxetine
3) Confidence 0.24 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11191831 Disease Relevance 0 Pain Relevance 0.61
Indeed, we have found that endogenous TRPC6 channels are sensitive to Ca2+ store depletion in neutrophil-like, DMSO-differentiated HL-60 cells [67], and TRPC3, in combination with TRPC1 or TRPC4, might be involved in SOCs formation [53].
Spec (like) Regulation (sensitive) of Localization (depletion) of Ca2 in neutrophil
4) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
They proposed that the exchange factor Ras-guanine nucleotide-releasing factor activity is regulated by Ca2+ mobilization through a mechanism involving the Ca2+-calmodulin complex.
Regulation (regulated) of Localization (mobilization) of Ca2
5) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.05 Pain Relevance 0.04
Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils.
Regulation (Effect) of Localization (mobilization) of Ca2 in basophils associated with lidocaine
6) Confidence 0.23 Published 1996 Journal Acta Anaesthesiol Scand Section Title Doc Link 8933856 Disease Relevance 0.19 Pain Relevance 0.28
It is established that under the action of ionophore A23187 tetracaine exerts no effect on mobilization of intracellular Ca2+.
Neg (no) Regulation (effect) of Localization (mobilization) of Ca2
7) Confidence 0.21 Published 1988 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 3137702 Disease Relevance 0 Pain Relevance 0.12
On the other hand, elevation of intraepithelial Ca2+ concentration by ?
Regulation (intraepithelial) of Localization (concentration) of Ca2
8) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0.05
Our results indicate that verapamil may not alter basal Ca2+ content, instead, the Ca2+ wave, possibly due to Ca2+ release from cytosolic compartments, was abolished (Fig. 11).
Neg (not) Spec (may) Regulation (alter) of Localization (release) of Ca2
9) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.20 Pain Relevance 0.05
Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils.
Regulation (Effect) of in mast cells Localization (mobilization) of Ca2 in basophils associated with lidocaine
10) Confidence 0.08 Published 1996 Journal Acta Anaesthesiol Scand Section Title Doc Link 8933856 Disease Relevance 0.19 Pain Relevance 0.28
The increment of Ca2+ concentration is mediated by voltage-gated Ca2+ channels that regulate Ca2+ influx across the plasma membrane and control the release of Ca2+ from intracellular stores.
Regulation (control) of Localization (release) of Ca2 in plasma
11) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.19 Pain Relevance 0.15
When probed pharmacologically, the signalling caused by LTXN4C involved the activation of phospholipase C and release of Ca2+ from intracellular stores (Davletov et al., 1998; Capogna et al., 2003) and the same type of signal transduction was directly attributed to latrophilin in C. elegans (Willson et al., 2004) and in a model system (latrophilin-transfected neuroblastoma cells; Volynski et al., 2004).
Regulation (involved) of Localization (release) of Ca2 associated with neuroblastoma
12) Confidence 0.01 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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