INT353288

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.03

nucleus (Smad7, Tgif1) nucleolus (Smad7) plasma membrane (Smad7) intracellular (Smad7) DNA binding (Tgif1) protein complex (Smad7)

Anatomy Link Frequency fibroblasts 2 Smad7 (Mus musculus) Tgif1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 25 62.52 fibrosis 7 5.00 cytokine 5 5.00 anesthesia 2 5.00 ketamine 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 25 62.52 Burns 10 5.00 Fibrosis 8 5.00 Keloid Scars 4 5.00 Disease 3 5.00 Injury 2 5.00 Syndrome 1 5.00 Internal Fibrosis 1 5.00 Conjunctivitis 1 5.00 Wound Healing 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of our study show that TSA upregulates Smad7 (an inhibitory Smad that blocks phosphorylation of Smad2/3) and TGIF (a co-repressor of Smad-dependent gene expression that directly associates with Smad proteins) and inhibits Smad-mediated transcriptional activation in cultured subconjunctival fibroblasts.

Smad7 Negative_regulation (blocks) of Phosphorylation (phosphorylation) of TGIF in fibroblasts

1) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

This test has worked.