INT353292

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prdx2) mitochondrion (Prdx2) oxidoreductase activity (Prdx2)
nucleus (Tgif1) DNA binding (Tgif1) cytoplasm (Prdx2)
Anatomy Link Frequency
fibroblasts 1
Prdx2 (Mus musculus)
Tgif1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 63.16 Quite High
fibrosis 7 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 63.16 Quite High
Burns 10 5.00 Very Low Very Low Very Low
Fibrosis 8 5.00 Very Low Very Low Very Low
Keloid Scars 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Internal Fibrosis 1 5.00 Very Low Very Low Very Low
Conjunctivitis 1 5.00 Very Low Very Low Very Low
Wound Healing 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of our study show that TSA upregulates Smad7 (an inhibitory Smad that blocks phosphorylation of Smad2/3) and TGIF (a co-repressor of Smad-dependent gene expression that directly associates with Smad proteins) and inhibits Smad-mediated transcriptional activation in cultured subconjunctival fibroblasts.
TSA Positive_regulation (upregulates) of TGIF in fibroblasts
1) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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