INT3533

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Context Info
Confidence 0.37
First Reported 1976
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 10.84
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 5
blood 2
cleavage 1
brain 1
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 23 100.00 Very High Very High Very High
beta blocker 3 99.48 Very High Very High Very High
Calcium channel 3 98.88 Very High Very High Very High
Inflammation 68 97.12 Very High Very High Very High
Calcitonin gene-related peptide 20 96.16 Very High Very High Very High
Central nervous system 2 94.72 High High
Clonidine 4 94.64 High High
Migraine 1 84.96 Quite High
Bioavailability 30 83.48 Quite High
cva 13 83.20 Quite High
Disease Link Frequency Relevance Heat
Hypoaldosteronism 3 99.98 Very High Very High Very High
Fatigue 39 99.80 Very High Very High Very High
Myocardial Infarction 137 99.32 Very High Very High Very High
Diabetes Mellitus 162 98.80 Very High Very High Very High
Heart Rate Under Development 42 98.74 Very High Very High Very High
Metabolic Syndrome 77 98.58 Very High Very High Very High
Hyperkalemia 27 98.42 Very High Very High Very High
Atherosclerosis 13 97.72 Very High Very High Very High
INFLAMMATION 66 97.12 Very High Very High Very High
Renal Failure 5 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment, the decline in renin value after resting was statistically significant: 42.7 +/- 3.3 ng/ml/16 h (p less than 0.05), and the stimulated renin had fallen to 70 +/- 3.4 ng/ml/16 h (p greater than 0.1).
renin Binding (fallen) of
1) Confidence 0.37 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 790007 Disease Relevance 0.67 Pain Relevance 0.09
Hyperpotassemia and bradycardia in a bedridden elderly woman with selective hypoaldosteronism associated with low renin activity.
renin Binding (associated) of associated with hypoaldosteronism, heart rate under development and hyperkalemia
2) Confidence 0.37 Published 2010 Journal Intern. Med. Section Title Doc Link 20154436 Disease Relevance 0.82 Pain Relevance 0.29
The used kits were commercial radioimmunoassays for ACTH, renin and angiotensin II provided by Nichols Institute Diagnostics, San Juan Capistrano, USA, and for aldosterone and cortisol by DRG Instruments GmbH, Marburg, Germany.
renin Binding (radioimmunoassays) of
3) Confidence 0.36 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.08 Pain Relevance 0
In particular in MS+ patients with myocardial infarction, this mechanism could negatively interact with the concomitant activation of circulating renin-angiotensin-system, thereby providing a reasonable explanation for the greater preventive effects of ACE inhibition observed in the SMILE Study (Prasad and Quyyumi 2004).
renin Neg (negatively) Binding (interact) of associated with metabolic syndrome and myocardial infarction
4) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515426 Disease Relevance 1.20 Pain Relevance 0.03
It was further elucidated that binding of renin to this receptor resulted in significant increase in its catalytic efficiency in Ang I formation (Nguyen et al 2002).
renin Binding (binding) of
5) Confidence 0.34 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.24 Pain Relevance 0
Renin was found to bind to this receptor with high affinity, but binding of renin to this receptor was not attenuated by renin inhibitors, indicating that the renin catalytic site is distinct from the receptor binding site.
Renin Binding (bind) of
6) Confidence 0.34 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.26 Pain Relevance 0
Moreover, this receptor also binds prorenin that, when bound to the receptor, would have renin-like action.
renin Binding (bound) of
7) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.14 Pain Relevance 0
Moreover, this receptor also binds prorenin that, when bound to the receptor, would have renin-like action.
renin Binding (binds) of
8) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.20 Pain Relevance 0
The binding of renin to its receptor triggers intracellular signals by rapid activation of mitogen-activated protein kinases, ie, extracellular signal-regulated protein kinases 1 and 2, and may increase plasma activator inhibitor-1 – a prothrombotic agent – levels via this mechanism.
renin Binding (binding) of in plasma
9) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.06 Pain Relevance 0
Furthermore, the bound renin has increased catalytic efficiency for the cleavage of angiotensinogen to form Ang I, facilitating Ang II production (by ACE or vascular muscle smooth chymase) at the cell surface.
renin Binding (bound) of in cleavage
10) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.15 Pain Relevance 0
Renin, simply considered until recently as the rate-limiting enzyme of RAAS activation, has also turned out to be the ligand for a protein known as the renin/prorenin receptor (RPR), which binds renin and prorenin about equally, regardless of their biologic activities.3 Prorenin, which represents 70%–90% of total circulating renin, when bound to the RPR, induces an increase in the catalytic efficiency of angiotensinogen conversion to Ang I, which contributes to local production of Ang II and its systemic levels, as well as binding of renin/prorenin to the RPR, exerting physiologic effects that are independent of Ang II, including activation of intracellular signal pathways, enhanced synthesis of DNA, and stimulation of the release of plasminogen activator inhibitor (PAI-1), collagen-1, fibronectin, and transforming growth factor beta-1.3
renin Binding (binds) of
11) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.15 Pain Relevance 0
The third-generation compounds benefited from advances in crystallography and a structure-based approach to drug design, which led to the development of aliskiren.7,9 Molecular modeling was used to design and modify the aliskiren molecule, the structure of which was based on x-ray crystallographic analysis of the active site of renin.8 Aliskiren interacts with several binding pockets in distinct regions around the active site of renin, in particular, the renin subpocket (S3sp).8 Compared with peptidomimetic renin inhibitors, aliskiren has lower lipophilicity, which renders it more resistant to intestinal degradation.
renin Binding (interacts) of
12) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0 Pain Relevance 0.08
The age, degree of renal impairment, plasma renin activity, and number and dosage of antihypertensive medicines did not account for these differences in NE.
plasma renin Neg (not) Binding (account) of in plasma
13) Confidence 0.27 Published 1981 Journal Clin. Nephrol. Section Abstract Doc Link 7296970 Disease Relevance 0.46 Pain Relevance 0.25
The rate of generation of angiotensin in ex-vivo plasma, or plasma renin activity (PRA), was assayed using a commercial radioimmune assay (RIA) kit (DiaSorin, Stillwater, MN, USA).
plasma renin Binding (generation) of in plasma
14) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.13 Pain Relevance 0.07
Sixty minutes after the test meal, ANP decreased renin concentrations by 30 ± 5% (P = 0.05 vs. placebo).


renin Binding (concentrations) of
15) Confidence 0.22 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.14 Pain Relevance 0
In addition, all had normal renal function, both for glomerular (GFR, RPF, FF) and tubular parameters (FENa), and their plasma renin activity and aldosterone levels were within the normal range.
renin Binding (activity) of in plasma
16) Confidence 0.21 Published 2006 Journal BMC Pediatr Section Body Doc Link PMC1434736 Disease Relevance 0.32 Pain Relevance 0
Then we used three GAM models to assess whether PM10 modified the association of temperature with health outcomes: a nonparametric bivariate response model, a nonstratification model, and a stratification model (Ren and Tong, in press; Roberts 2004).
Ren Spec (whether) Binding (association) of
17) Confidence 0.14 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.36 Pain Relevance 0
Our recent study also found that temperature significantly modified the association between PM10 and health outcomes (Ren and Tong, in press).
Ren Binding (association) of
18) Confidence 0.14 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.08 Pain Relevance 0
The low levels of Ang-(1–7) and ACE2 in the RUPP model may represent an inhibition of the vasodilator arm of the renin-angiotensin system associated with factors generated by the reduced placental blood flow (sFlt-1, TNF-?
renin Binding (associated) of in blood
19) Confidence 0.14 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.08 Pain Relevance 0
Vasodilator component of renin-angiotensin system
renin Binding (component) of
20) Confidence 0.14 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.06 Pain Relevance 0

General Comments

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