INT353314

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Edn1, Kalrn) extracellular space (Edn1) extracellular region (Edn1)
cytoskeleton (Kalrn) intracellular (Kalrn) cell-cell signaling (Edn1)
Anatomy Link Frequency
smooth muscle 2
Edn1 (Rattus norvegicus)
Kalrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 16 84.72 Quite High
ischemia 2 21.44 Low Low
agonist 6 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 84.72 Quite High
Hypersensitivity 10 71.44 Quite High
Increased Venous Pressure Under Development 18 53.84 Quite High
Atherosclerosis 2 24.96 Low Low
Diabetes Mellitus 2 23.36 Low Low
Hypertension 4 22.56 Low Low
Cv Unclassified Under Development 2 21.44 Low Low
Cv General 4 Under Development 12 19.44 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in further experiments we aimed to analyze if endothelin-1, which reportedly also activates the Rho-kinase signaling pathway in the cerebrovascular smooth muscle [28], may also induce vasomotional activity in NOS-blocked MCAs.
endothelin-1 Positive_regulation (activates) of Rho-kinase in smooth muscle
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.05 Pain Relevance 0
It has been recently demonstrated that endothelin-1, already at low concentrations, activates the RhoA – Rho-kinase pathway in the cerebrovascular smooth muscle [28].
endothelin-1 Positive_regulation (activates) of Rho-kinase in smooth muscle
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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