INT353330

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) aging (Mif) cytoplasm (Mif)
signal transducer activity (F2r) cell proliferation (Mif) extracellular space (Mif)
Anatomy Link Frequency
bladder 2
F2r (Rattus norvegicus)
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 9 95.52 Very High Very High Very High
Inflammation 22 39.36 Quite Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
substance P 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 39.36 Quite Low
Cancer 4 10.16 Low Low
Cystitis 4 5.00 Very Low Very Low Very Low
Interstitial Cystitis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real time RT-PCR showed that thrombin stimulation resulted in upregulation of MIF mRNA in the bladder (2-fold increase compared to saline treatment; p0.001; Dunnet's test) while treatment with lidocaine reduced the effect of thrombin on MIF mRNA upregulation (1.4-fold increase when compared to saline treatment) so that it was not statistically significant from the saline treatment group (Table 1).


thrombin Positive_regulation (resulted) of Positive_regulation (upregulation) of MIF in bladder associated with lidocaine
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.26

General Comments

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