INT353334

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) aging (Mif) cytoplasm (Mif)
signal transducer activity (F2r) cell proliferation (Mif) extracellular space (Mif)
Anatomy Link Frequency
bladder 2
F2r (Rattus norvegicus)
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 27 99.52 Very High Very High Very High
agonist 15 44.88 Quite Low
Inflammation 66 40.68 Quite Low
cytokine 12 38.08 Quite Low
Inflammatory stimuli 15 5.00 Very Low Very Low Very Low
halothane 9 5.00 Very Low Very Low Very Low
interstitial cystitis 9 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 78 40.68 Quite Low
Cancer 12 5.00 Very Low Very Low Very Low
Cystitis 12 5.00 Very Low Very Low Very Low
Interstitial Cystitis 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombin evokes MIF release from rat bladder and upregulates bladder MIF mRNA
Thrombin Positive_regulation (upregulates) of MIF in bladder
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.05
Thrombin evokes MIF release and upregulates MIF mRNA UROtsa cells
Thrombin Positive_regulation (upregulates) of MIF
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Thrombin also upregulated MIF mRNA in UROtsa cells (3.3-fold increase) and in the rat bladder (2-fold increase) where the effect was reduced (1.4-fold) by lidocaine treatment.


Thrombin Positive_regulation (upregulated) of MIF in bladder associated with lidocaine
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.27

General Comments

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