INT353338

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.25
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) aging (Mif) cytoplasm (Mif)
signal transducer activity (F2r) cell proliferation (Mif) extracellular space (Mif)
Anatomy Link Frequency
bladder 4
endothelial cells 2
nerve 2
F2r (Rattus norvegicus)
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 176 98.52 Very High Very High Very High
lidocaine 72 98.12 Very High Very High Very High
substance P 16 92.84 High High
cytokine 32 83.16 Quite High
Inflammatory stimuli 40 73.52 Quite High
agonist 40 71.04 Quite High
interstitial cystitis 24 48.80 Quite Low
halothane 24 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Thoracotomy 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 208 98.52 Very High Very High Very High
Cystitis 32 80.40 Quite High
Cancer 32 79.36 Quite High
Neurogenic Inflammation 8 68.48 Quite High
Interstitial Cystitis 24 48.80 Quite Low
Apoptosis 8 32.56 Quite Low
Pain 8 5.00 Very Low Very Low Very Low
Overdose 8 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since PAR1 and MIF containing cells in rat urothelium are not located superficially, our findings that intravesical thrombin can induce MIF release from the rat bladder (presumably urothelium) suggest that intravesical thrombin was able to reach those cells to activate PAR1 receptors.
thrombin Positive_regulation (induce) of Localization (release) of MIF in bladder
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.14 Pain Relevance 0.04
Thrombin evokes MIF release from rat bladder and upregulates bladder MIF mRNA
Thrombin Positive_regulation (evokes) of Localization (release) of MIF in bladder
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Thrombin evokes MIF release and upregulates MIF mRNA UROtsa cells
Thrombin Positive_regulation (evokes) of Localization (release) of MIF
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Heat-inactivated thrombin was ineffective in stimulating MIF release from UROtsa cells which argues against this possibility.
thrombin Positive_regulation (stimulating) of Localization (release) of MIF
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.05 Pain Relevance 0
Our results thus confirm earlier findings of thrombin-induced MIF release from human endothelial cells [17] and we extend those results by showing that the same phenomenon occurs in vivo.
thrombin Positive_regulation (induced) of Localization (release) of MIF in endothelial cells
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Therefore, thrombin-induced MIF release represents another mechanism to initiate MIF release from the urothelium, aside from nerve-mediated release which has already been described [27], [28].
thrombin Positive_regulation (induced) of Localization (release) of MIF in nerve
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.34 Pain Relevance 0.26
Therefore, it is possible that intravesical thrombin may also be functioning in a similar manner to elicit MIF release.
thrombin Positive_regulation (elicit) of Localization (release) of MIF
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.71 Pain Relevance 0.60
In rats, thrombin-induced MIF release was reduced but not abolished by intravesical lidocaine treatment.
thrombin Positive_regulation (induced) of Localization (release) of MIF associated with lidocaine
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox