INT353362

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
granule cell 1
amd (Mus musculus)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 9 98.56 Very High Very High Very High
Hippocampus 35 93.68 High High
Inflammation 2 86.40 High High
cytokine 4 85.36 High High
Central nervous system 7 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 86.40 High High
Injury 3 83.76 Quite High
Death 4 76.04 Quite High
Convulsion 44 74.48 Quite High
Epilepsy 8 69.12 Quite High
Status Epilepticus 19 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies suggest that at least part of the mechanism for guiding new cells to their final position in the granule cell layer is the expression of CXCL12, as ESNPs show a directional migration toward a source of this chemokine in vitro, and their migration is truncated in vivo after infusion with AMD3100, an inhibitor of CXCR4.
AMD3100 Negative_regulation (inhibitor) of CXCR4 in granule cell associated with chemokine
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.52 Pain Relevance 0.33

General Comments

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