INT353408

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rnd3) intracellular (Rnd3)
Anatomy Link Frequency
fibroblasts 4
Rnd3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 296 100.00 Very High Very High Very High
Breast Cancer 8 99.68 Very High Very High Very High
Sarcoma 112 98.56 Very High Very High Very High
Reprotox - General 1 8 98.52 Very High Very High Very High
Skin Cancer 24 97.56 Very High Very High Very High
Malignant Neoplastic Disease 40 75.16 Quite High
Severe Combined Immunodeficiency 32 62.88 Quite High
Metastasis 128 47.20 Quite Low
Fibrosarcoma 8 33.60 Quite Low
Stress 16 24.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rnd3 shows reduced expression in prostate cancer and seems to have a protective role against breast cancer [25]; however, increased Rnd3 expression has been found in other epithelial tumors and in metastatic melanoma cells [42], suggesting that the genetic background of cancer cells can influence the role of Rnd3 in trasformation.
Positive_regulation (increased) of Gene_expression (expression) of Rnd3 associated with cancer, breast cancer, skin cancer and reprotox - general 1
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.81 Pain Relevance 0
Gadea et al. [14] showed that overexpression of Rnd3 in mouse embryonic fibroblasts in which amoeboid migration had been induced by p53 knockdown led to reduced invasion.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Rnd3 in fibroblasts
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.25 Pain Relevance 0
We analyzed the metastatic potential of Rnd3 clone 16, because of the greater stability of Rnd3 expression in this clone compared to that in clone 8 (not shown).
Positive_regulation (stability) of Gene_expression (expression) of Rnd3
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.35 Pain Relevance 0
Rnd3 overexpression induces actin fiber disassembly in several cell types [34].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Rnd3
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0
Our results indicate that reduced Rnd3 expression in tumor cells of mesenchymal origin can be linked to the acquisition of a ROCK-dependent mode of invasion and can increase the metastatic potential.
Positive_regulation (increase) of Gene_expression (expression) of Rnd3 associated with cancer
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.95 Pain Relevance 0
We then investigated whether exogenous Rnd3 expression reduced the in vivo metastatic potential of phase III tumorigenic cen3tel cells.
Spec (whether) Positive_regulation (exogenous) of Spec (whether) Gene_expression (expression) of Rnd3
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.19 Pain Relevance 0
By microarray analysis and western blotting we did not observe any evident change in ROCK or RhoA expression in tumorigenic cen3tel cells (data not shown); however, microarray and western blot analyses revealed that the cellular inhibitor of ROCK-I, Rnd3 (Riento et al. 2003), was expressed at lower levels in tumorigenic cen3tel cells compared to non-tumorigenic ones (Fig. 5A, B), suggesting that Rnd3 downregulation might play a role in the transition to the ROCK dependent mode of invasion.
Positive_regulation (levels) of Gene_expression (expressed) of Rnd3
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0
In fact, it has been shown that in mouse 3T3 fibroblasts, the strong effects induced by acute Rnd3 expression on the cytoskeleton are only transient and disappear within hours, even though the levels of the protein are still high [35].
Positive_regulation (induced) of Gene_expression (expression) of Rnd3 in fibroblasts
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0

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