INT353424

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rnd3) intracellular (Rnd3)
Rnd3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 222 99.84 Very High Very High Very High
Sarcoma 84 99.60 Very High Very High Very High
Skin Cancer 18 94.72 High High
Breast Cancer 6 90.32 High High
Reprotox - General 1 6 88.00 High High
Fibrosarcoma 6 86.64 High High
Stress 12 77.92 Quite High
Metastasis 96 71.92 Quite High
Malignant Neoplastic Disease 30 53.44 Quite High
Severe Combined Immunodeficiency 24 48.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that reduced Rnd3 expression in tumor cells of mesenchymal origin can be linked to the acquisition of a ROCK-dependent mode of invasion and can increase the metastatic potential.
Negative_regulation (reduced) of Gene_expression (expression) of Rnd3 associated with cancer
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.87 Pain Relevance 0
The increased invasiveness of tumorigenic cells was associated with reduced expression of Rnd3 (also known as RhoE), a cellular inhibitor of ROCK.
Negative_regulation (reduced) of Gene_expression (expression) of Rnd3
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3014295 Disease Relevance 0.33 Pain Relevance 0
At the molecular level, this switch could be linked to two main changes: the decrease in the expression of matrix protease genes and the reduced expression of the Rho GTP-binding protein Rnd3.
Negative_regulation (reduced) of Gene_expression (expression) of Rnd3
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.33 Pain Relevance 0
At the molecular level, this switch could be linked to two main changes: the decrease in the expression of matrix protease genes and the reduced expression of the Rho GTP-binding protein Rnd3.
Negative_regulation (decrease) of Gene_expression (expression) of Rnd3
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.34 Pain Relevance 0
We then investigated whether exogenous Rnd3 expression reduced the in vivo metastatic potential of phase III tumorigenic cen3tel cells.
Spec (whether) Negative_regulation (reduced) of Spec (whether) Gene_expression (expression) of Rnd3
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.19 Pain Relevance 0
Very little is known about Rnd3 expression in human sarcomas.
Negative_regulation (known) of Gene_expression (expression) of Rnd3 associated with sarcoma
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.86 Pain Relevance 0

General Comments

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