INT353435

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pdpk1, Rock1) kinase activity (Pdpk1, Rock1) Golgi apparatus (Rock1)
cytosol (Pdpk1) signal transduction (Pdpk1) plasma membrane (Pdpk1)
Anatomy Link Frequency
plasma 1
Pdpk1 (Mus musculus)
Rock1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 3 96.60 Very High Very High Very High
Cancer 37 91.04 High High
Malignant Neoplastic Disease 5 83.60 Quite High
Fibrosarcoma 1 42.04 Quite Low
Stress 2 33.32 Quite Low
Reprotox - General 1 1 20.80 Low Low
Sarcoma 14 16.44 Low Low
Breast Cancer 1 16.00 Low Low
Metastasis 16 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDK1 drives ROCK-I to the plasma membrane where it stimulates actomyosin phosphorylation and contraction, while Rnd3 can bind to ROCK-I and inhibit its activity, reducing motility.
PDK1 Binding (drives) of ROCK-I in plasma
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.27 Pain Relevance 0

General Comments

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