INT353437

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0

nucleoplasm (Trp53, Cdkn2a) DNA binding (Trp53, Cdkn2a) protein complex (Trp53, Cdkn2a) cytoplasm (Trp53, Cdkn2a) nucleolus (Trp53, Cdkn2a) nucleus (Trp53, Cdkn2a)

Trp53 (Mus musculus) Cdkn2a (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 37 89.92 Malignant Neoplastic Disease 5 75.24 Sarcoma 14 74.84 Carcinoma 4 70.20 Metastasis 16 69.68 Severe Combined Immunodeficiency 4 5.00 Skin Cancer 3 5.00 Synovial Sarcoma 2 5.00 Stress 2 5.00 Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studying cells at different phases of transformation, we could show that an early event during transformation was the loss of expression of the CDKN2A locus, followed by inactivation of p53 and overexpression of c-myc.

Negative_regulation (inactivation) of p53 Positive_regulation (followed) of Gene_expression (expression) of CDKN2A

1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.59 Pain Relevance 0

General Comments

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