INT353437

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53, Cdkn2a) DNA binding (Trp53, Cdkn2a) protein complex (Trp53, Cdkn2a)
cytoplasm (Trp53, Cdkn2a) nucleolus (Trp53, Cdkn2a) nucleus (Trp53, Cdkn2a)
Trp53 (Mus musculus)
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 37 89.92 High High
Malignant Neoplastic Disease 5 75.24 Quite High
Sarcoma 14 74.84 Quite High
Carcinoma 4 70.20 Quite High
Metastasis 16 69.68 Quite High
Severe Combined Immunodeficiency 4 5.00 Very Low Very Low Very Low
Skin Cancer 3 5.00 Very Low Very Low Very Low
Synovial Sarcoma 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studying cells at different phases of transformation, we could show that an early event during transformation was the loss of expression of the CDKN2A locus, followed by inactivation of p53 and overexpression of c-myc.
Negative_regulation (inactivation) of p53 Positive_regulation (followed) of Gene_expression (expression) of CDKN2A
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.59 Pain Relevance 0

General Comments

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