INT353438

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rnd3, Rock1) cytoskeleton (Rock1) intracellular (Rnd3)
cytoskeleton organization (Rock1) kinase activity (Rock1) cytoplasm (Rock1)
Rnd3 (Mus musculus)
Rock1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 30 98.64 Very High Very High Very High
Metastasis 96 97.76 Very High Very High Very High
Sarcoma 84 96.80 Very High Very High Very High
Cancer 222 95.32 Very High Very High Very High
Skin Cancer 18 79.76 Quite High
Reprotox - General 1 6 78.24 Quite High
Breast Cancer 6 73.44 Quite High
Fibrosarcoma 6 57.08 Quite High
Stress 12 48.36 Quite Low
Carcinoma 24 39.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the low levels of myosin phosphorylation in Rnd3 transfected clones is in agreement with the hypothesis that Rnd3 hampers amoeboid movement by inhibiting ROCK kinase activity.
Rnd3 Negative_regulation (inhibiting) of ROCK kinase
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.58 Pain Relevance 0
We show here that Rnd3 (also known as RhoE), a cellular inhibitor of ROCK-I [25], plays a relevant role in regulating invasion and metastasis formation of sarcoma cells.


Rnd3 Negative_regulation (inhibitor) of ROCK-I associated with sarcoma and metastasis
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.45 Pain Relevance 0
In the Rnd3 expressing clones we did find lower level of p-MLC than in parental and mock-transfected cells, which could be due to an Rnd3-induced reduction in ROCK kinase activity (Fig. 5F).
Rnd3 Negative_regulation (reduction) of ROCK kinase
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0
We show here that Rnd3 (also known as RhoE), a cellular inhibitor of ROCK-I [25], plays a relevant role in regulating invasion and metastasis formation of sarcoma cells.


RhoE Negative_regulation (inhibitor) of ROCK-I associated with sarcoma and metastasis
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.44 Pain Relevance 0
The increased invasiveness of tumorigenic cells was associated with reduced expression of Rnd3 (also known as RhoE), a cellular inhibitor of ROCK.
Rnd3 Negative_regulation (inhibitor) of ROCK
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3014295 Disease Relevance 0.27 Pain Relevance 0
Rnd3 is an inhibitor of ROCK-I [32], [40] and evidence has been reported that it can play a role in controlling morphology and invasion of rounded tumor cells.
Rnd3 Negative_regulation (inhibitor) of ROCK-I associated with cancer
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.33 Pain Relevance 0

General Comments

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