INT35349

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 52
Total Number 56
Disease Relevance 25.36
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CENPJ) cytoskeleton (CENPJ) cell division (CENPJ)
cytoplasm (CENPJ)
Anatomy Link Frequency
respiratory 9
lung 6
nasal 2
Stage 3 1
heart 1
CENPJ (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 43 99.56 Very High Very High Very High
anesthesia 43 98.70 Very High Very High Very High
depression 199 98.08 Very High Very High Very High
Serotonin 78 97.60 Very High Very High Very High
nud 9 95.24 Very High Very High Very High
alcohol 79 93.92 High High
analgesia 12 90.72 High High
antidepressant 22 90.32 High High
fluoxetine 17 87.80 High High
Neurobehavioral 11 86.96 High High
Disease Link Frequency Relevance Heat
Obstructive Sleep Apnea 1540 100.00 Very High Very High Very High
Pulmonary Disease 206 99.98 Very High Very High Very High
Apnoea 1083 99.88 Very High Very High Very High
Cardiovascular Disease 148 99.86 Very High Very High Very High
Sleep Disorders 540 99.40 Very High Very High Very High
Central Sleep Apnea 160 99.28 Very High Very High Very High
Hypertension 212 99.12 Very High Very High Very High
Airway Obstruction 54 98.72 Very High Very High Very High
Adult Respiratory Distress Syndrome 126 98.68 Very High Very High Very High
Depression 277 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examiner versus Patient's Ratings on the SASS
Spec (Examiner) Gene_expression (Examiner) of SASS
1) Confidence 0.57 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951137 Disease Relevance 0.85 Pain Relevance 0.06
As anesthesia resolved, the rate of APRV breaths was decreased until patients breathed only with CPAP.
Gene_expression (breathed) of CPAP associated with anesthesia
2) Confidence 0.51 Published 1988 Journal Chest Section Abstract Doc Link 3139372 Disease Relevance 0.16 Pain Relevance 0.10
In our patients, CPAP produced a rapid physiological and symptomatic improvement in patients with ACPE, especially within the first hours, as also been observed with other CPAP modalities [21].
Gene_expression (produced) of CPAP associated with heart rate under development
3) Confidence 0.51 Published 2007 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2233641 Disease Relevance 0.75 Pain Relevance 0
The exuberance regarding nasal CPAP therapy in patients with central apnea and CHF did not withstand the rigors of controlled clinical trials.
Gene_expression (therapy) of CPAP in nasal associated with central sleep apnea
4) Confidence 0.49 Published 2008 Journal Heart Fail Rev Section Body Doc Link PMC2698052 Disease Relevance 0.89 Pain Relevance 0
Optimal CPAP pressure was not determined.
Spec (determined) Gene_expression (pressure) of CPAP
5) Confidence 0.49 Published 2008 Journal Heart Fail Rev Section Body Doc Link PMC2698052 Disease Relevance 0.34 Pain Relevance 0
The aim of this study was to compare the respiratory effects of two RMs, a continuous positive airway pressure (CPAP) and an eSigh, in patients with ARDS under protective mechanical ventilation.
Gene_expression (effects) of CPAP in respiratory associated with adult respiratory distress syndrome
6) Confidence 0.47 Published 2008 Journal Crit Care Section Body Doc Link PMC2447604 Disease Relevance 0.82 Pain Relevance 0.04
A significantly higher Pmax may explain, in part, why 5 patients were CPAP responders whereas 11 were eSigh responders.
Gene_expression (responders) of CPAP
7) Confidence 0.47 Published 2008 Journal Crit Care Section Body Doc Link PMC2447604 Disease Relevance 0.05 Pain Relevance 0
However, the analysis failed to show a significant difference in improvement in psychosocial functioning, as measured by the SASS, between the reboxetine and SSRI groups, although the SASS was not used in all studies.


Neg (not) Gene_expression (used) of SASS associated with ssri
8) Confidence 0.43 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2951748 Disease Relevance 0 Pain Relevance 0.57
There are no agreed standards on techniques of CPAP titration and it is likely there is considerable variability between laboratories.
Gene_expression (titration) of CPAP
9) Confidence 0.40 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.33 Pain Relevance 0
McArdle and Douglas (2001) reported that CPAP resulted in a significant improvement in arousals during sleep and redistribution of Stage 1 sleep to deeper Stage 3/4 (slow wave) sleep compared with oral placebo.
Gene_expression (resulted) of CPAP in Stage 3
10) Confidence 0.40 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.34 Pain Relevance 0
APAP has been consistently shown to deliver lower average airway pressures relative to conventional fixed-pressure CPAP (Konerman et al 1998; D’Ortho et al 2000; Hudgel and Fung 2000; Teschler et al 2000; Randerath et al 2001; Massie et al 2003; Hukins 2004), with APAP delivering a lower mean pressure of 0.9–4.2 cm H2O.
Gene_expression (pressure) of CPAP
11) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.07 Pain Relevance 0
Most studies have not shown a difference between CPAP and MAS therapy in subjective sleepiness (Tan et al 2002; Barnes et al 2004) although CPAP is more effective in reducing AHI (Ferguson et al 1997; Barnes et al 2004).
Gene_expression (therapy) of CPAP associated with sleep disorders
12) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.72 Pain Relevance 0
In view of the increasing evidence of an association between OSA and cardiovascular disease, does CPAP reduce the risk of cardiovascular complications?
Gene_expression (reduce) of CPAP associated with cardiovascular disease and obstructive sleep apnea
13) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.87 Pain Relevance 0
Means et al (2004) reported that patients who underwent home CPAP titration had lower nightly CPAP usage than those who underwent laboratory titration (3.9 vs 5.0 hours per night).
Gene_expression (usage) of CPAP
14) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.15 Pain Relevance 0
The one study comparing APAP with fixed-pressure CPAP specifically in subjects with high within-night variability in pressure requirement (related to sleep position, sleep stages, or other factors such as alcohol) did not show improved compliance, although subjective sleepiness assessed by the Epworth Sleepiness Score was significantly lower statistically but not clinically with APAP (Noseda et al 2004).
Gene_expression (pressure) of CPAP associated with sleep disorders and alcohol
15) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.34 Pain Relevance 0.09
A 1997 systematic review of the health consequences of OSA and effectiveness of CPAP concluded that the pubic health risk of OSA was exaggerated and was highly critical of the paucity of high quality evidence supporting this therapy (Wright et al 1997).
Gene_expression (effectiveness) of CPAP associated with obstructive sleep apnea
16) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.26 Pain Relevance 0
Becker et al (2003) showed much larger falls in diurnal and nocturnal blood pressure of about 10 mmHg (diastolic, systolic and mean) in patients with moderate to severe OSA treated with effective CPAP compared with a sub-therapeutic CPAP setting which reduced respiratory disturbance by only 50%.
Gene_expression (setting) of CPAP in respiratory associated with obstructive sleep apnea
17) Confidence 0.35 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.38 Pain Relevance 0
This may seem in contrast with previous studies that have generally shown that leptin levels decrease significantly with CPAP [36-41,48], but these changes were generally small in absolute amount and not very different from those determined here.
Gene_expression (decrease) of CPAP
18) Confidence 0.29 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 0.62 Pain Relevance 0
The CPAP group received FiO2 ?
Gene_expression (group) of CPAP
19) Confidence 0.19 Published 2004 Journal Crit Care Section Body Doc Link PMC420062 Disease Relevance 0.10 Pain Relevance 0.03
0.4 and CPAP ?
Gene_expression (0.4) of CPAP
20) Confidence 0.19 Published 2004 Journal Crit Care Section Body Doc Link PMC420062 Disease Relevance 0.10 Pain Relevance 0.03

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