INT3535

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Context Info
Confidence 0.32
First Reported 1976
Last Reported 2010
Negated 8
Speculated 4
Reported most in Body
Documents 61
Total Number 66
Disease Relevance 16.48
Pain Relevance 10.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
neutrophils 3
external 2
cardiomyocytes 2
macrophages 1
plasma 1
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 10 100.00 Very High Very High Very High
alcohol 98 99.82 Very High Very High Very High
Opioid 39 99.56 Very High Very High Very High
agonist 172 99.50 Very High Very High Very High
TRP channel 21 99.46 Very High Very High Very High
qutenza 30 99.24 Very High Very High Very High
Chronic pancreatitis 12 99.16 Very High Very High Very High
Kinase C 34 98.88 Very High Very High Very High
Morphine 35 97.74 Very High Very High Very High
imagery 84 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 61 99.96 Very High Very High Very High
Disease 624 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 61 99.56 Very High Very High Very High
Neuroblastoma 49 99.52 Very High Very High Very High
Stress 120 99.48 Very High Very High Very High
Pancreatitis 13 99.16 Very High Very High Very High
Adhesions 35 98.56 Very High Very High Very High
Apoptosis 207 98.52 Very High Very High Very High
Alzheimer's Dementia 199 98.52 Very High Very High Very High
Death 97 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
REGULATION OF Ca2+ INFLUX BY ACTIVATION OF THE NADPH OXIDASE
Regulation (REGULATION) of Ca2
1) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.08 Pain Relevance 0
-mediated aggregation and secretion and the G12/Rho-mediated shape change while cGMP/PKG signaling inhibits the former Gq/Ca2+ dependent mechanism but does not affect the latter RhoA/Ca2+ independent mechanism [35].
Neg (not) Regulation (affect) of Ca2
2) Confidence 0.28 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Regulation (affect) of Ca2 in reticulum
3) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Thus our studies have contributed to basic knowledge of regulation of Ca2+ release function.
Regulation (regulation) of Ca2
4) Confidence 0.27 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9137560 Disease Relevance 0.17 Pain Relevance 0.08
Modulation of Ca2+ channel subtypes could be a general mechanism for drugs of abuse to regulate the release of specific neurotransmitters at central nervous system synapses.
Regulation (Modulation) of Ca2 in synapses associated with neurotransmitter and central nervous system
5) Confidence 0.26 Published 2005 Journal J. Neuroendocrinol. Section Abstract Doc Link 16101897 Disease Relevance 0 Pain Relevance 0.37
Normal saline infusion at 100 ml/70 kg/min caused no change in Ca2+; however, plasma protein administration at this rate resulted in an 18% decrease in Ca2+, presumably as a consequence of the binding of calcium ions to anionic sites on plasma protein.
Neg (no) Regulation (change) of Ca2 in plasma
6) Confidence 0.24 Published 1976 Journal Br J Anaesth Section Abstract Doc Link 791314 Disease Relevance 0.25 Pain Relevance 0
CONCLUSIONS: Ethanol, even at nontoxic concentrations, has a direct effect on aortic smooth muscle Ca2+i, large enough to be associated with significant vasoconstriction.
Regulation (effect) of Ca2 in smooth muscle
7) Confidence 0.24 Published 1996 Journal Reg Anesth Section Body Doc Link 8826019 Disease Relevance 0 Pain Relevance 0
2 integrin-induced Ca2+ influx seems dependent on the formation of InsP3 [39].
Spec (seems) Regulation (dependent) of Ca2
8) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.44 Pain Relevance 0.04
Indeed, it is shown that translocation of cPLA2 is dependent on [Ca2+]c elevation [143, 144], and PKC?
Regulation (dependent) of Ca2
9) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Given the critical involvement of [Ca2+]c elevation in the regulation of ROS generation and thus, in the proinflammatory activities of neutrophils, Ca2+ channel inhibition holds considerable therapeutic promise.
Regulation (involvement) of Ca2 in neutrophils
10) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.91 Pain Relevance 0.18
The opioid-induced increase in [Ca2+]i was not affected by treatments modifying the trimeric Gl, Go, and Gs protein transduction mechanisms or the activity of adenylyl cyclase.
Neg (not) Regulation (affected) of Ca2 associated with opioid
11) Confidence 0.22 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8931479 Disease Relevance 0.16 Pain Relevance 0.61
The range of [Ca2+]i values over which Pcat activation increases in all the RBCs was far above physiological [Ca2+]i levels; at the [Ca2+]s levels of 50 ?
Regulation (range) of Ca2
12) Confidence 0.22 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
The experiment of Figure 5 shows the effect of increasing Ca2+ concentrations on the rehydration response.
Regulation (effect) of Ca2
13) Confidence 0.22 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
These results suggest that cultured neural cells provide a useful system to study Ca2+ regulation via ion channels.
Regulation (regulation) of Ca2 in neural
14) Confidence 0.22 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2452233 Disease Relevance 0.24 Pain Relevance 0.39
As shown in Figure 3B and 3C, mRNA and protein expression of CFTR and CAII were significantly up-regulated upon stimulation of E.coli-LPS, respectively.
Regulation (regulated) of CAII
15) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.69 Pain Relevance 0.42
Because VGCC appears to be the primary target underlying the rapid inhibitory effects of opioids[17,18] and morphine stimulation of MOR1K increases intracellular Ca2+ levels in COS1 cells (Fig.2B), we examined the dose-dependent regulation of Ca2+ levels in neuroblastoma BE2C cells transiently transfected with MOR1K (Fig.2C).
Spec (examined) Regulation (regulation) of Ca2 associated with neuroblastoma, opioid and morphine
16) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.19 Pain Relevance 0.64
Cell migration relies on a tight temporal and spatial regulation of the intracellular Ca2+ concentration ([Ca2+]i).
Regulation (regulation) of Ca2
17) Confidence 0.19 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17184838 Disease Relevance 0.13 Pain Relevance 0.33
Cell migration relies on a tight temporal and spatial regulation of the intracellular Ca2+ concentration ([Ca2+]i).
Regulation (regulation) of Ca2
18) Confidence 0.19 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17184838 Disease Relevance 0.13 Pain Relevance 0.33
We then investigated the consequences of the E2 treatment on the Ca2+ signal induced by Icilin.
Spec (investigated) Regulation (consequences) of Ca2
19) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.10 Pain Relevance 0
In addition, caffeine acts directly on the voltage-dependent Ca2+ channels in the plasmatic membrane to inhibit the entrance of Ca2+ [37], an effect which is independent of its antiphosphodiesterase action [38].
Regulation (acts) of Ca2
20) Confidence 0.17 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0.07 Pain Relevance 0

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