INT353561

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 15.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SELENBP1) nucleolus (SELENBP1) nucleus (SELENBP1)
cytoplasm (SELENBP1)
Anatomy Link Frequency
uterine 10
colon 5
lungs 5
myometrium 2
stomach 1
SELENBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
pain pelvic 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 1292 99.84 Very High Very High Very High
Cancer 459 99.56 Very High Very High Very High
Apoptosis 17 95.80 Very High Very High Very High
Colon Cancer 17 95.28 Very High Very High Very High
Ovarian Cancer 17 88.56 High High
Breast Cancer 17 81.72 Quite High
Endometriosis (extended) 17 72.68 Quite High
Generaliased Trisomy 17 66.24 Quite High
Adenocarcinoma 17 48.48 Quite Low
Obesity 17 19.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study showing a decreased expression of SELENBP1 in uterine leiomyoma not only indicates a role of SELENBP1 in tumorigenesis but also suggests the potential utility of selenium in prevention and treatment of uterine leiomyoma.
Negative_regulation (decreased) of Gene_expression (expression) of SELENBP1 in uterine associated with uterine fibroids
1) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.14 Pain Relevance 0
It is likely that additional genetic and molecular events contribute to tumorigenesis, but reduction of SELENBP1 expression may be a key step in the transition from normal myometrium to leiomyoma.
Negative_regulation (reduction) of Gene_expression (expression) of SELENBP1 in myometrium associated with uterine fibroids
2) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.20 Pain Relevance 0
Although there was a trend for a decreased expression of SELENBP1 with increasing tumor size (Figure 2), no statistical difference was seen among four arbitrary size groups: ?
Negative_regulation (decreased) of Gene_expression (expression) of SELENBP1 associated with cancer
3) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.84 Pain Relevance 0
When the expression of SELENBP1 is reduced, however, leiomyoma may develop because selenium without adequate SELENBP1 may be incapable of inhibiting the stimulatory actions of estrogens.
Negative_regulation (reduced) of Gene_expression (expression) of SELENBP1 associated with uterine fibroids
4) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.63 Pain Relevance 0
The expression of SELENBP1 has been shown to be decreased in several tumors including cancers of the prostate, lungs, colon, and ovary [23-26].
Negative_regulation (decreased) of Gene_expression (expression) of SELENBP1 in colon associated with cancer
5) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.16 Pain Relevance 0
Since the effects of selenium are mediated by SELENBP1, loss of SELENBP1 expression in leiomyoma may have a negative impact on the ability of selenium to control tumor cell growth.
Negative_regulation (loss) of Gene_expression (expression) of SELENBP1 associated with uterine fibroids and cancer
6) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.14 Pain Relevance 0
Indeed, decreased expression of SELENBP1 in even the smallest leiomyoma (i.e., 1 cm) examined suggests that alteration in SELENBP1 expression may be an early event in the development of the tumor.
Spec (examined) Negative_regulation (decreased) of Spec (examined) Gene_expression (expression) of SELENBP1 associated with uterine fibroids and cancer
7) Confidence 0.59 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.22 Pain Relevance 0
Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis.
Negative_regulation (Decreased) of Gene_expression (expression) of selenium-binding protein 1 in uterine associated with uterine fibroids
8) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC3014888 Disease Relevance 0.77 Pain Relevance 0
The expression of selenium-binding protein 1 is decreased in uterine leiomyoma

Background

Negative_regulation (decreased) of Gene_expression (expression) of selenium-binding protein 1 in uterine associated with uterine fibroids
9) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Title Doc Link PMC3014888 Disease Relevance 0.83 Pain Relevance 0
Although loss of SELENBP1 expression may be secondary to tumor development, the ability of SELENBP1 to inhibit cell proliferation and induce apoptosis in colon cancer [30] may suggest that the protein may also be involved in tumorigenesis of uterine leiomyoma.
Negative_regulation (loss) of Gene_expression (expression) of SELENBP1 in uterine associated with uterine fibroids, cancer, colon cancer and apoptosis
10) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.10 Pain Relevance 0
Decreased expression of selenium-binding protein 1 has been reported in cancers of the prostate, stomach, colon, and lungs.
Negative_regulation (Decreased) of Gene_expression (expression) of selenium-binding protein 1 in lungs associated with cancer
11) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC3014888 Disease Relevance 0.52 Pain Relevance 0
The decrease of SELENBP1 expression in uterine leiomyoma suggests that SELENBP1 is related to the development of this tumor.
Negative_regulation (decrease) of Gene_expression (expression) of SELENBP1 in uterine associated with uterine fibroids and cancer
12) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.10 Pain Relevance 0
In order to evaluate whether patient's age was related to the level of SELENBP1, we divided patients into two arbitrary age groups: <45 years and ?
Spec (whether) Negative_regulation (related) of Gene_expression (level) of SELENBP1
13) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.62 Pain Relevance 0
The expression of SELENBP1 has been shown to be decreased in several tumors including cancers of the prostate, lungs, colon, and ovary [23-26].
Negative_regulation (decreased) of in lungs Gene_expression (expression) of SELENBP1 in colon associated with cancer
14) Confidence 0.20 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.16 Pain Relevance 0
The expression of SELENBP1 has been shown to be decreased in several tumors including cancers of the prostate, lungs, colon, and ovary [23-26].
Negative_regulation (decreased) of in ovary Gene_expression (expression) of SELENBP1 in colon associated with cancer
15) Confidence 0.20 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.16 Pain Relevance 0
Decreased expression of selenium-binding protein 1 has been reported in cancers of the prostate, stomach, colon, and lungs.
Negative_regulation (Decreased) of in stomach Gene_expression (expression) of selenium-binding protein 1 in lungs associated with cancer
16) Confidence 0.15 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC3014888 Disease Relevance 0.52 Pain Relevance 0
Decreased expression of selenium-binding protein 1 has been reported in cancers of the prostate, stomach, colon, and lungs.
Negative_regulation (Decreased) of in colon Gene_expression (expression) of selenium-binding protein 1 in lungs associated with cancer
17) Confidence 0.15 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC3014888 Disease Relevance 0.52 Pain Relevance 0

General Comments

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