INT35359

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 9.13
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (LCT) plasma membrane (LCT) carbohydrate metabolic process (LCT)
Anatomy Link Frequency
intestinal cells 1
body 1
LCT (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 125 99.24 Very High Very High Very High
nud 18 98.12 Very High Very High Very High
narcan 5 97.76 Very High Very High Very High
Pain 52 92.48 High High
Opioid 5 86.72 High High
antagonist 1 79.96 Quite High
opiate 1 79.52 Quite High
alcohol 9 74.72 Quite High
imagery 1 73.04 Quite High
Inflammation 71 51.96 Quite High
Disease Link Frequency Relevance Heat
Malabsorption Syndromes 48 100.00 Very High Very High Very High
Obesity 57 99.86 Very High Very High Very High
Metabolic Disorder 1 99.82 Very High Very High Very High
Diarrhoea 26 99.76 Very High Very High Very High
Abdominal Pain 125 99.24 Very High Very High Very High
Giardiasis 7 98.84 Very High Very High Very High
Flatulence 12 98.60 Very High Very High Very High
Dyspepsia 18 98.12 Very High Very High Very High
Genetic Predisposition To Disease 5 97.72 Very High Very High Very High
Hypoglycemia 6 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hereditary persistence of lactase is common primarily in people of northern European descent and is attributed to inheritance of an autosomal-dominant mutation that prevents the maturational decline in lactase expression.
Negative_regulation (persistence) of lactase
1) Confidence 0.59 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.70 Pain Relevance 0.08
Importantly, the ancestral allele at MCPH1 is found at significant frequencies among current European populations (22%, International HapMap Project, http://hapmap.ncbi.nlm.nih.gov/index.html.en, refSNP rs930557) and a significant fraction of the Southern European population is actually lactase deficient (eg. 64,3% in Northern Italy [18]).
Negative_regulation (deficient) of lactase
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
Lactase levels were decreased significantly (p < 0.05) in giardiasis.
Negative_regulation (decreased) of Lactase associated with giardiasis
3) Confidence 0.45 Published 2000 Journal Trop Gastroenterol Section Abstract Doc Link 11194577 Disease Relevance 0.78 Pain Relevance 0.14
At some point in prehistory, a genetic mutation occurred and lactase activity persisted in a majority of the adult population of Northern and Central Europe. 2) Persistence of intestinal lactase, the uncommon trait worldwide, is inherited as a highly penetrant autosomal-dominant characteristic.
Negative_regulation (persisted) of lactase
4) Confidence 0.43 Published 1988 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 3140651 Disease Relevance 0.07 Pain Relevance 0
The maturational decline in lactase activity renders most of the world's adult human population intolerant of excessive consumption of milk and other dairy products.
Negative_regulation (decline) of lactase
5) Confidence 0.43 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.44 Pain Relevance 0.05
The identification of genetic variants associated with lactase persistence or nonpersistence allows for molecular detection of the genetic predisposition towards adult-onset hypolactasia by DNA sequencing or restriction fragment length polymorphism analysis.
Negative_regulation (persistence) of lactase associated with genetic predisposition to disease
6) Confidence 0.43 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.62 Pain Relevance 0.07
Recent reports have identified genetic polymorphisms that are closely associated with lactase persistence and nonpersistence phenotypes.
Negative_regulation (persistence) of lactase
7) Confidence 0.43 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.64 Pain Relevance 0.07
1) Most humans, like other mammals, gradually lose the intestinal enzyme lactase after infancy and with it the ability to digest lactose, the principle sugar in milk.
Negative_regulation (lose) of lactase
8) Confidence 0.43 Published 1988 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 3140651 Disease Relevance 0.07 Pain Relevance 0
In spite of the absence of a specific history of milk/milk product intolerance a lactose H (2)-breath test was performed showing lactase deficiency with lactose intolerance.
Negative_regulation (deficiency) of lactase associated with malabsorption syndromes
9) Confidence 0.42 Published 2007 Journal Z Gastroenterol Section Abstract Doc Link 17304404 Disease Relevance 1.07 Pain Relevance 0.12
The activity of the lactase enzyme in intestinal cells normally declines during childhood.
Negative_regulation (declines) of lactase in intestinal cells
10) Confidence 0.41 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830824 Disease Relevance 0.36 Pain Relevance 0.14
Mitochondrial DNA analysis indicates that African-Brazilians carry the relative ancestral contribution of central-west, southeast, and west Africa [10], where the LCT-13910T variant of lactase persistence of Europeans in Africa was present [5].
Negative_regulation (persistence) of LCT-13910T variant
11) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0 Pain Relevance 0
Genetically programmed down-regulation of the lactase gene (adult-type hypolactasia) is detectable in children from the second year of life, although the onset and extent are somewhat variable [1].
Negative_regulation (regulation) of lactase
12) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0.29 Pain Relevance 0.11
Assuming an association between LCT-13910CC genotype and hypolactasia, and LCT-13910CT and TT genotypes with lactase persistence, 356 (62.8%) individuals had hypolactasia and 211 (37.2%) had lactase persistence.
Negative_regulation (persistence) of lactase
13) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0 Pain Relevance 0
Assuming an association between CC genotype and hypolactasia, and CT and TT genotypes with lactase persistence, 356 (62.8%) individuals had hypolactasia and 211 (37.2%) had lactase persistence.
Negative_regulation (persistence) of lactase
14) Confidence 0.39 Published 2009 Journal Nutr J Section Abstract Doc Link PMC2761420 Disease Relevance 0 Pain Relevance 0
Mitochondrial DNA analysis indicates that African-Brazilians carry the relative ancestral contribution of central-west, southeast, and west Africa [10], where the LCT-13910T variant of lactase persistence of Europeans in Africa was present [5].
Negative_regulation (persistence) of lactase
15) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0 Pain Relevance 0
Lactase non-persistence is the most common phenotype in humans, with frequencies around 65%, except in northwestern Europe with its long history of pastoralism and milking [3].
Negative_regulation (persistence) of Lactase
16) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0.40 Pain Relevance 0.15
Black-Brazilians have the LCT-13910T variant of lactase persistence although at a low frequency.
Negative_regulation (persistence) of lactase
17) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0.06 Pain Relevance 0
Black-Brazilians have the LCT-13910T variant of lactase persistence although at a low frequency.
Negative_regulation (persistence) of LCT-13910T variant
18) Confidence 0.39 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0.06 Pain Relevance 0
Administered separately, naloxone was associated with a significant fall in PRL levels (p less than 0.01), a significant and unexpected rise in GH levels (p less than 0.02), and a suppression of the circadian decrease of ACTH and LPH levels.
Negative_regulation (decrease) of LPH associated with narcan
19) Confidence 0.32 Published 1982 Journal Nouv Presse Med Section Abstract Doc Link 6280130 Disease Relevance 0.39 Pain Relevance 0.67
Haplotype analysis implied that the associated variants are in the LCT gene itself, and not necessarily related to the lactase persistence variant upstream of the gene.
Negative_regulation (persistence) of lactase
20) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.55 Pain Relevance 0

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