INT35366

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 87
Total Number 89
Disease Relevance 30.52
Pain Relevance 8.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
coronary artery 1
mammary gland 1
hinge 1
thyroid 1
respiratory systems 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 751 100.00 Very High Very High Very High
antagonist 294 100.00 Very High Very High Very High
Desipramine 11 100.00 Very High Very High Very High
tricyclic antidepressant 10 100.00 Very High Very High Very High
Bioavailability 7 99.52 Very High Very High Very High
Catecholamine 17 99.40 Very High Very High Very High
cytokine 76 98.92 Very High Very High Very High
Inflammation 198 98.56 Very High Very High Very High
Pain 50 98.16 Very High Very High Very High
monoamine 11 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rhinitis 179 100.00 Very High Very High Very High
Graft Vs Host Disease 26 100.00 Very High Very High Very High
Shock 15 100.00 Very High Very High Very High
Sickle Cell Anemia 10 100.00 Very High Very High Very High
Stress 55 99.98 Very High Very High Very High
Asthma 162 99.76 Very High Very High Very High
Prostate Cancer 1012 99.60 Very High Very High Very High
Cancer 819 99.44 Very High Very High Very High
Pruritus 11 99.24 Very High Very High Very High
Endometriosis (extended) 25 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The receptor functions as a transcriptional factor and together with other co-regulatory proteins (coactivators and co-repressors) which may associate with the AR-ligand complex control transcriptional activity.
AR Binding (associate) of
1) Confidence 0.47 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.15 Pain Relevance 0.13
After binding to its ligand, androgen, AR forms a homodimer and regulates androgen responsive genes via androgen response elements.
AR Binding (binding) of
2) Confidence 0.47 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.11 Pain Relevance 0.15
Other molecular events, such as mutations broadening the ligand spectrum, or conferring agonist properties to androgen antagonists, alterations in nuclear receptor coactivators, ligand-independent binding of AR to DNA, were also implicated in AR signaling in CRCaP [4], [5].
AR Binding (binding) of associated with antagonist and agonist
3) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.64 Pain Relevance 0.15
The possible explanation could be an aberrant interaction between an androgen receptor coregulatory proteins and the receptor itself.
androgen receptor Binding (interaction) of
4) Confidence 0.36 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.60 Pain Relevance 0.08
Two of the mutations were located in the AF-2 domain of androgen receptor which is essential for coactivator binding and its signaling.
androgen receptor Binding (binding) of
5) Confidence 0.36 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.49 Pain Relevance 0.13
Moreover, it was shown that the interaction of the AR with other proteins of the intracellular signal transduction cascade may promote prostate tumor growth.
AR Binding (interaction) of associated with prostate cancer
6) Confidence 0.36 Published 2001 Journal Eur. Urol. Section Abstract Doc Link 11684838 Disease Relevance 0.65 Pain Relevance 0.11
Previous studies have implicated VAV3 in the pathogenesis of the prostate: (i) VAV3 expression has been detected in the prostate, at increased levels in cancer cells [67]; (ii) it has been shown to interact with the AR pathway, stimulating ligand-independent cell growth in LNCAP-hormone-refractory cells [67], [68], and (iii) targeting of constitutively active VAV3 expression to the prostate induced PCa in mice [69].
AR Binding (interact) of in LNCAP associated with cancer and prostate cancer
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.01 Pain Relevance 0
The prevalence of recognized DHTR was three (4%) of 73.
DHTR Binding (recognized) of
8) Confidence 0.35 Published 1988 Journal Arch. Intern. Med. Section Abstract Doc Link 3142382 Disease Relevance 0.56 Pain Relevance 0.08
In addition, AR is associated with asthma and other co-morbidities such as conjunctivitis and sinusitis.
AR Binding (associated) of associated with asthma, conjunctivitis, rhinitis and sinusitis
9) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2504079 Disease Relevance 1.53 Pain Relevance 0.11
The ligand-binding domain of the AR was found to be highly similar to other AR and contains the amino acids that are thought to be important for DHT interaction with the human AR [20,21].
AR Binding (binding) of
10) Confidence 0.32 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0 Pain Relevance 0
Propranolol bound to at least two classes of binding sites (kd1 was 2.56 X 10(-6)M-1; n1 = 0.58).
kd1 Binding (bound) of in M-1
11) Confidence 0.29 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 4074387 Disease Relevance 0 Pain Relevance 0.34
PC346Flu1, on the other hand, expresses high levels of the AR and previously showed a “super-activation” of this receptor in response to androgens, both in transactivation assays as in expression microarray analysis (unpublished data) [20].
AR Binding (levels) of
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.14 Pain Relevance 0
In the absence of androgens, MAPK and AKT kinases may induce AR phosphorylation and activation, whereas STAT3 can bind ligand-free AR and facilitate its translocation to the nucleus.
AR Binding (bind) of in nucleus
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.30 Pain Relevance 0
Taken together, our data suggest that unliganded AR supports basal OAT expression (Figure 3A) without further stimulation by DHT (Figure 2L), while basal MRFAP1 expression is suppressed by unliganded AR (Figure 3F), yet stimulated by DHT (Figure 2J).


AR Binding (unliganded) of
14) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.13 Pain Relevance 0
For many genes near AR-occupied regions, ligand-bound AR had the same qualitative effects in the two cell lines, except they were stronger in the C4-2B as compared to the LNCaP model (e.g., DDT, PRKCD, GSTT2, PYCR1; Figure 2).
AR Binding (bound) of
15) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.34 Pain Relevance 0
Although most of the regions occupied by the AR in C4-2B cells (a model of castrate-resistant PCa) were also occupied in LNCaP cells (a model of androgen-dependent PCa) (Table 1), we suspected that the functional consequences of AR occupancy at these loci might differ between the two cell lines.
AR Binding (occupancy) of associated with prostate cancer
16) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.20 Pain Relevance 0
The enhancement of basal activity was entirely blocked (-50 +/- 3%) by ligands that thus appeared to act as inverse agonists (i.e., RX 811059 and its (+)-enantiomer, (+)-RX 821002, RS 15385, and yohimbine); the potencies of the ligands corresponded with their binding affinities for the alpha(2A)-AR.
AR Binding (affinities) of associated with agonist
17) Confidence 0.27 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10640303 Disease Relevance 0.05 Pain Relevance 0.30
The present study was undertaken to identify such genes based on their physical interaction with the AR.
AR Binding (interaction) of
18) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.94 Pain Relevance 0
ARE have been identified in the coding region of AR cDNA from rat and shown to be functional, but require interaction with Myc family protein [45].
AR cDNA Binding (interaction) of
19) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.07 Pain Relevance 0
Although several studies have determined either the ligand binding affinity of AR or the trans-activation of AR, there are few studies dealing with both aspects.
AR Binding (affinity) of
20) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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