INT3537

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Context Info
Confidence 0.56
First Reported 1976
Last Reported 2011
Negated 8
Speculated 12
Reported most in Abstract
Documents 413
Total Number 430
Disease Relevance 103.51
Pain Relevance 94.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
neurons 27
myocytes 11
neuronal 9
astrocytes 7
internal 6
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 1592 100.00 Very High Very High Very High
long-term potentiation 1082 100.00 Very High Very High Very High
Kinase C 941 100.00 Very High Very High Very High
nMDA receptor 862 100.00 Very High Very High Very High
Calcium channel 273 100.00 Very High Very High Very High
Glutamate 1808 99.98 Very High Very High Very High
Morphine 894 99.98 Very High Very High Very High
qutenza 741 99.98 Very High Very High Very High
Action potential 710 99.98 Very High Very High Very High
Glutamate receptor 467 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 912 99.96 Very High Very High Very High
Reperfusion Injury 126 99.96 Very High Very High Very High
Diabetes Mellitus 408 99.92 Very High Very High Very High
Depression 725 99.84 Very High Very High Very High
Injury 615 99.84 Very High Very High Very High
Ganglion Cysts 564 99.84 Very High Very High Very High
Aging 188 99.84 Very High Very High Very High
Anaerobic Bacterial Infections 22 99.82 Very High Very High Very High
Nociception 539 99.80 Very High Very High Very High
Inflammatory Pain 323 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recorded photon flux in selected regions of interest plotted as a function of time indicates that a marked increase in [Ca2+] levels occurred in all areas approximately 15 minutes after drug administration (Figure 7B & C).
Positive_regulation (increase) of Ca2
1) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.25 Pain Relevance 0.08
Increased Ca2+ signalling, Ca2+ extrusion from cells, and Glu transport into glial cells
Positive_regulation (Increased) of Ca2 in glial cells associated with glutamate
2) Confidence 0.50 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.18 Pain Relevance 0.16
Inhibition of PDE4 by rolipram affected neither the extent of [Ca2+]i increase in response to each conditioning stimulation (Figure 7C) nor the basal GABAAR responsiveness (Supplementary Table 1).
Positive_regulation (increase) of Ca2
3) Confidence 0.47 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation.
Positive_regulation (activation) of Ca2 associated with cataract
4) Confidence 0.43 Published 2001 Journal J Ocul Pharmacol Ther Section Title Doc Link 11572469 Disease Relevance 0.35 Pain Relevance 0.10
The [Ca2+]i transients were initiated around the stimulus position within 10 ms and increased in size up to 30 ms after stimulation.
Positive_regulation (increased) of Ca2
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966408 Disease Relevance 0.05 Pain Relevance 0
These results indicated that action potentials involved in the induction of the [Ca2+]i transients (see Discussion).


Positive_regulation (induction) of Ca2 associated with action potential
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966408 Disease Relevance 0 Pain Relevance 0.05
These results suggested that the action potential contributed to the induction of the [Ca2+]i transients, and that excitatory synaptic connections were involved in the propagation of the high [Ca2+]i region in the primary visual cortical circuit.
Positive_regulation (induction) of Ca2 associated with action potential
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2966408 Disease Relevance 0 Pain Relevance 0.20
However, other investigators have reported that the inactivation of Ca2+-ATPase is closely related with ischemic heart disease, heart failure, and hypertrophy of cardiac muscle; thus, as the intracellular Ca2+ concentration increases, the concentration of ryanodine receptor decreases, and in some cases, down regulation has been found to be associated with the decreased expression of its mRNA.23,24
Positive_regulation (inactivation) of Ca2 in heart associated with hypertrophy, coronary artery disease and myocardial infarction
8) Confidence 0.41 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.35 Pain Relevance 0
Exposure of L1210 cells to the quinone, menadione, also increased the releasable pools of cellular Ca2+ but like adriamycin, only after an incubation period of 4 hr.
Positive_regulation (increased) of Ca2 in L1210
9) Confidence 0.41 Published 1987 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 2439346 Disease Relevance 0.45 Pain Relevance 0.08
However, cell death and a subsequent increase in cytosolic [Ca2+] proceeded unabated following N-acetylcysteine addition.
Positive_regulation (increase) of Ca2 associated with death
10) Confidence 0.41 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8513431 Disease Relevance 0.64 Pain Relevance 0.61
The increase in cytosolic [Ca2+] with acetaminophen alone and with subsequent N-acetylcysteine addition was determined to be a secondary event in cell injury because cytotoxicity occurred by 1.5 h; however, the increase in cytosolic [Ca2+] was not observed until 2.5 h.
Positive_regulation (increase) of Ca2 associated with paracetamol and injury
11) Confidence 0.41 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8513431 Disease Relevance 0.54 Pain Relevance 0.54
Dithiothreitol prevented both further cell injury and an increase in the cytosolic [Ca2+].
Positive_regulation (increase) of Ca2 associated with injury
12) Confidence 0.41 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8513431 Disease Relevance 0.64 Pain Relevance 0.62
The increase in cytosolic [Ca2+] with acetaminophen alone and with subsequent N-acetylcysteine addition was determined to be a secondary event in cell injury because cytotoxicity occurred by 1.5 h; however, the increase in cytosolic [Ca2+] was not observed until 2.5 h.
Spec (determined) Positive_regulation (increase) of Ca2 associated with paracetamol and injury
13) Confidence 0.41 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8513431 Disease Relevance 0.58 Pain Relevance 0.61
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.
Positive_regulation (accumulation) of Ca2 in nucleus associated with paracetamol and injury
14) Confidence 0.41 Published 1990 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 2256122 Disease Relevance 0.39 Pain Relevance 0.48
Periodic variations in mitochondrial [Ca2+] in whole body imaging of newborn mice
Positive_regulation (variations) of Ca2 in body associated with imagery
15) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.21
Whole animal recordings of light emission during induced Ca2+ concentration changes in hindlimb muscle mitochondria during contraction/relaxation cycles are well correlated with previously reported data obtained by fluorescence microscopy in both in vivo [8] and in vitro [8], [26] studies.
Positive_regulation (induced) of Ca2 in hindlimb muscle
16) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.33 Pain Relevance 0.07
Elevated Ca2+ activity appeared both as a slow rise in the basal concentration and as oscillations in which Ca2+ spikes only lasted a few seconds (Figure 7B & C, (ii) & (iii)).
Positive_regulation (Elevated) of Ca2 in spikes
17) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.24 Pain Relevance 0.08
Cold stress produced a transient increase in the regional levels of Ca2+ in the mouse brain.
Positive_regulation (increase) of Ca2 in brain associated with stress
18) Confidence 0.41 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6419254 Disease Relevance 0.19 Pain Relevance 0.14
Lithium sulphate produced a small increase of brain Ca2+ 24 h after a high and toxic dose.
Positive_regulation (increase) of Ca2 in brain
19) Confidence 0.41 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6419254 Disease Relevance 0.19 Pain Relevance 0.14
Local application of kainic acid and tetrodotoxine to the rat striatum had no acute effects, but kainic acid produced a five to tenfold increase in the levels of striatal Ca2+ 2 weeks after injection.
Positive_regulation (increase) of Ca2 in striatum
20) Confidence 0.41 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6419254 Disease Relevance 0.18 Pain Relevance 0.12

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