INT353716

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Context Info
Confidence 0.33
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ghrl, Vta1) endosome (Vta1) transport (Vta1)
extracellular space (Ghrl) extracellular region (Ghrl)
Anatomy Link Frequency
cell group 1
Ghrl (Mus musculus)
Vta1 (Mus musculus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 68 100.00 Very High Very High Very High
Dopamine 73 99.96 Very High Very High Very High
antagonist 44 87.60 High High
midbrain 1 81.84 Quite High
agonist 1 67.24 Quite High
cocaine 2 63.52 Quite High
alcohol 7 55.84 Quite High
Opioid 7 45.36 Quite Low
Glutamate 6 44.20 Quite Low
nMDA receptor antagonist 3 38.36 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 2 5.00 Very Low Very Low Very Low
Hyperphagia 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Hypothermia 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with previous neuroanatomical and accumbal dopamine measurement studies showing that the target cells for ghrelin in the VTA include the dopaminergic cell group (Abizaid et al. 2006; Jerlhag et al. 2006; Jerlhag 2008; Kawahara et al. 2009; Quarta et al. 2009), it seems likely that peripheral ghrelin directly activates the VTA dopamine system via GHS-R1A.
ghrelin Positive_regulation (activates) of VTA in cell group associated with ventral tegmentum and dopamine
1) Confidence 0.33 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.74

General Comments

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