INT353720

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Context Info
Confidence 0.18
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a, Ghsr) plasma membrane (Drd1a, Ghsr) signal transducer activity (Drd1a, Ghsr)
endoplasmic reticulum (Drd1a) nucleus (Drd1a) intracellular (Drd1a)
Anatomy Link Frequency
dopamine neurons 1
Drd1a (Mus musculus)
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 73 100.00 Very High Very High Very High
Ventral tegmentum 68 97.84 Very High Very High Very High
antagonist 44 80.96 Quite High
cocaine 2 78.00 Quite High
midbrain 1 75.20 Quite High
alcohol 7 70.32 Quite High
agonist 1 60.60 Quite High
Neurotransmitter 3 39.36 Quite Low
Opioid 7 38.72 Quite Low
Glutamate 6 37.56 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 2 5.00 Very Low Very Low Very Low
Hyperphagia 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Hypothermia 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of the mesolimbic dopamine system by ghrelin may be due to the reported ability of the GHS-R1A to dimerize with the dopamine D1 receptor, both receptors expressed on dopamine neurons in the VTA, and thereby amplifies the dopamine signalling (Jiang, Betancourt & Smith 2006).
dopamine D1 receptor Binding (dimerize) of GHS-R1A in dopamine neurons associated with ventral tegmentum and dopamine
1) Confidence 0.18 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.76

General Comments

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