INT353741

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Context Info
Confidence 0.00
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.16
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
spleen 1
IGHE (Homo sapiens)
Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Infliximab 88 99.24 Very High Very High Very High
rheumatoid arthritis 60 94.96 High High
methotrexate 16 56.24 Quite High
headache 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 8 97.74 Very High Very High Very High
Hypersensitivity 6 96.80 Very High Very High Very High
Rheumatoid Arthritis 60 94.96 High High
Disease 10 5.00 Very Low Very Low Very Low
Fever 6 5.00 Very Low Very Low Very Low
Emergencies 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Erythema 4 5.00 Very Low Very Low Very Low
Urticaria 4 5.00 Very Low Very Low Very Low
Headache 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown using radiolabelled infliximab in patients with RA that the formation of infliximab and anti-infliximab complexes were found in non-responders, one of which showed an anaphylactoid reaction, resulting in higher liver/spleen uptake and rapid clearance of infliximab.11 It was recently observed that the IgE class of AIA is associated with the development of severe infusion reactions,26 whereas true IgE-mediated hypersensitivity is not related to acute infusion reactions in most cases.27 This possibility in one patient who developed an anaphylactoid reaction in this cohort remains to be addressed.
IgE Binding (associated) of AIA in spleen associated with infliximab, anaphylaxis, hypersensitivity and rheumatoid arthritis
1) Confidence 0.00 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.58 Pain Relevance 0.53
It has been shown using radiolabelled infliximab in patients with RA that the formation of infliximab and anti-infliximab complexes were found in non-responders, one of which showed an anaphylactoid reaction, resulting in higher liver/spleen uptake and rapid clearance of infliximab.11 It was recently observed that the IgE class of AIA is associated with the development of severe infusion reactions,26 whereas true IgE-mediated hypersensitivity is not related to acute infusion reactions in most cases.27 This possibility in one patient who developed an anaphylactoid reaction in this cohort remains to be addressed.
IgE Binding (associated) of AIA in liver associated with infliximab, anaphylaxis, hypersensitivity and rheumatoid arthritis
2) Confidence 0.00 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.58 Pain Relevance 0.53

General Comments

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