INT353784

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
neural 1
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 14 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 98.62 Very High Very High Very High
Hyperlipidemia 38 97.84 Very High Very High Very High
Hyperlipoproteinemia Type Ii 132 92.36 High High
Targeted Disruption 30 90.28 High High
Congenital Anomalies 6 85.36 High High
Disorder Of Lipid Metabolism 36 67.84 Quite High
Disease 22 46.40 Quite Low
Atherosclerosis 32 5.00 Very Low Very Low Very Low
Coronary Artery Disease 24 5.00 Very Low Very Low Very Low
Infection 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The convertase subtilisin/kexin type 9 (PCSK9)-gene codes for an enzyme that has also been called neural apoptosis regulated convertase 1, which has been proposed to be involved in degrading the LDLR protein in the lysosome and thus preventing it from recycling [8].
Protein_catabolism (degrading) of LDLR protein in neural associated with apoptosis
1) Confidence 0.52 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.78 Pain Relevance 0
This causes a delay in the post-translational processing of the 120 kDa LDLR-precursor to the 160 kDa mature form, leading to premature degradation of the mature form in the cytoplasm and consequently hypercholesterolaemia (700-1200 mg/dl at 12 months of age) [79].
Protein_catabolism (degradation) of LDLR-precursor associated with hyperlipidemia
2) Confidence 0.45 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 1.07 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox