INT353787

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.36 Pain Relevance 0

peptidase activity (Pcsk9) extracellular space (Pcsk9) extracellular region (Pcsk9) lipid metabolic process (Pcsk9) lysosome (Pcsk9)

Pcsk9 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 7 5.00 Inflammation 2 5.00 cytokine 1 5.00 fibrosis 1 5.00 Arthritis 1 5.00 headache 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Hyperlipidemia 19 97.24 Hyperlipoproteinemia Type Ii 66 96.46 Disorder Of Lipid Metabolism 18 91.44 Erythema 1 76.40 Cold Sores 1 47.44 Epstein-barr Virus 4 19.16 Atherosclerosis 16 5.00 Targeted Disruption 15 5.00 Coronary Artery Disease 12 5.00 Disease 11 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While the majority of studies were focused on treating FH by inhibition of hypercholesterolaemia through up-regulation of LDLR or other surrogate lipoprotein receptors (as will be discussed later), an alternative approach was to down-regulate apoB-100 LDLR-ligand or PCSK9 [63] expression.

Regulation (regulate) of Gene_expression (expression) of PCSK9 associated with hyperlipoproteinemia type ii and hyperlipidemia

1) Confidence 0.24 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.36 Pain Relevance 0

General Comments

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