INT35380

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.84
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) extracellular region (Fn1) cell adhesion (Fn1)
proteinaceous extracellular matrix (Fn1) extracellular matrix organization (Fn1)
Anatomy Link Frequency
extracellular matrix 1
EPI 1
Fn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 8 98.92 Very High Very High Very High
methotrexate 7 98.68 Very High Very High Very High
Arthritis 7 98.48 Very High Very High Very High
cINOD 3 91.88 High High
aspirin 2 90.00 High High
Inflammation 15 86.56 High High
rheumatoid arthritis 4 85.44 High High
Spinal cord 75 85.32 High High
anesthesia 1 84.00 Quite High
ketamine 1 83.56 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 12 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 99.84 Very High Very High Very High
Solid Tumor 1 99.76 Very High Very High Very High
Hyperalgesia 8 98.92 Very High Very High Very High
Experimental Arthritis 6 98.48 Very High Very High Very High
Fever 3 93.96 High High
Acute-phase Reaction 6 93.76 High High
Adhesions 4 90.72 High High
Lung Cancer 5 90.56 High High
INFLAMMATION 17 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excellent guidelines for FN treatment have recently been published; however, there has so far been insufficient research concerning FN associated with solid tumors, especially in Japan.
FN Binding (associated) of associated with neutropenia and solid tumor
1) Confidence 0.35 Published 2010 Journal J. Infect. Chemother. Section Abstract Doc Link 20130951 Disease Relevance 1.46 Pain Relevance 0
Since CS-A and MTX have been reported to be effective in the treatment of RA, their activity in the LAF, Fn, CRP, albumin and iron assays of the AA rat suggests that these immunological and serological parameters may be useful in identifying potential antirheumatic drugs and distinguishing them from standard NSAIDs.
Fn Binding (activity) of associated with rheumatoid arthritis, cinod, methotrexate and arthritis
2) Confidence 0.34 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 3143680 Disease Relevance 0.95 Pain Relevance 0.66
Cryofiltration (CRYO) removes cryogel, which is a combination of fibrinogen (Fbg) and fibronectin (FN), containing pathological substances.
FN Binding (combination) of
3) Confidence 0.33 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.39 Pain Relevance 0.15
Cryofiltration (CRYO) removes cryogel, which is a combination of fibrinogen (Fbg) and fibronectin (FN), containing pathological substances.
fibronectin Binding (combination) of
4) Confidence 0.33 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.39 Pain Relevance 0.15
Monoclonal antibodies (mAbs) against the alpha1 or alpha3 integrin subunits, which participate in laminin binding, selectively blocked PGE2 hyperalgesia, while a mAb against the alpha5 subunit, which participates in fibronectin binding, blocked only EPI-induced hyperalgesia.
fibronectin Binding (binding) of in EPI associated with hyperalgesia
5) Confidence 0.31 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14984413 Disease Relevance 1.23 Pain Relevance 1.06
In another interesting study, the cell-adhesive sequence Arg-Gly-Asp (RGD) of the central-binding domain of the extracellular matrix (ECM) glycoprotein fibronectin was incorporated into the NeuroGel (PHPMA-RGD hydrogel).
fibronectin Binding (binding) of in extracellular matrix
6) Confidence 0.19 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.25 Pain Relevance 0.10
The cells were then suspended in DMEM/F12 (Invitrogen, Carlsbad, CA) supplemented with 5 µg/ml insulin (Sigma), 50 µg/ml transferrin (Sigma), 30 nM selenium chloride (Sigma), and 5 µg/ml fibronectin (Sigma) (ITSFn medium), followed by magnetic separation of A2B5+ cells.
fibronectin Binding (supplemented) of
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.13
Galectin-3 mainly binds to glycosylated proteins of the matrix, including laminin, fibronectin, and tenascin [11, 12].
fibronectin Binding (binds) of
8) Confidence 0.03 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox