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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.25
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 16 92.24 High High
Clonidine 1 91.40 High High
antagonist 12 88.76 High High
Spinal cord 1 81.76 Quite High
5HT 45 79.68 Quite High
induced neuropathy 1 75.00 Quite High
Kinase C 1 75.00 Quite High
Glutamate 7 63.28 Quite High
Catecholamine 1 59.24 Quite High
nMDA receptor 8 30.40 Quite Low
Disease Link Frequency Relevance Heat
Poisoning 1 99.60 Very High Very High Very High
Neuropathic Pain 1 75.00 Quite High
Pheochromocytoma 1 75.00 Quite High
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Mental Disorders 2 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein phosphorylation of neurofilament proteins, as well as MAP-2 was significantly decreased upon treatment.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of MAP-2
1) Confidence 0.44 Published 1988 Journal Brain Res. Section Abstract Doc Link 3145093 Disease Relevance 0.17 Pain Relevance 0.12
Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of MAP-2c
2) Confidence 0.42 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.25
Moreover, our previous findings have suggested that 5-HT1A reduces ERK activity, which in turn reduces MAP2 phosphorylation and microtubule stability (21).
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of MAP2
3) Confidence 0.13 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.19

General Comments

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