INT35390

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Context Info
Confidence 0.81
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.06
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
neuronal 3
neurites 1
SK-N-SH 1
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 68 99.70 Very High Very High Very High
ischemia 61 98.32 Very High Very High Very High
Kinase C 7 98.00 Very High Very High Very High
Catecholamine 9 97.72 Very High Very High Very High
agonist 37 91.04 High High
Clonidine 7 90.20 High High
antagonist 29 87.56 High High
cva 1 85.12 High High
Spinal cord 1 81.76 Quite High
5HT 91 79.36 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 7 99.68 Very High Very High Very High
Poisoning 1 99.60 Very High Very High Very High
Stress 7 98.80 Very High Very High Very High
Cv Unclassified Under Development 49 98.32 Very High Very High Very High
Disease 2 92.48 High High
Death 16 85.76 High High
Cv General 3 Under Development 1 85.12 High High
Stroke 1 78.96 Quite High
Hematoma 1 78.00 Quite High
Apoptosis 3 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to determine the effect of activation of adrenoceptor by epinephrine on MAP-2 phosphorylation in differentiation PC12 cells and, if so, to explore the mediating mechanism.
Spec (determine) Phosphorylation (phosphorylation) of MAP-2
1) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.22
These findings suggest that epinephrine induces phosphorylation of MAP-2c at ser136 through a alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neurites.
Phosphorylation (phosphorylation) of MAP-2c in neurites
2) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.20
We found that epinephrine could significantly increase the phosphorylation of MAP-2c at ser136 in a dose- and time-dependent manner in differentiated PC12 cells as well as microtubule arrays.
Phosphorylation (phosphorylation) of MAP-2c
3) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.24
Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.
Phosphorylation (phosphorylation) of MAP-2c
4) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.25
Epinephrine increases phosphorylation of MAP-2c in rat pheochromocytoma cells (PC12 Cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.
Phosphorylation (phosphorylation) of MAP-2c associated with kinase c and pheochromocytoma
5) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Title Doc Link 18290605 Disease Relevance 0.10 Pain Relevance 0.22
Microtubule-associated protein-2 (MAP-2) is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity.
Phosphorylation (phosphorylation) of MAP-2 in neuronal
6) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.11
Microtubule-associated protein-2 (MAP-2) is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity.
Phosphorylation (phosphorylation) of Microtubule-associated protein-2 in neuronal
7) Confidence 0.81 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.11
On the other hand, fluoxetine was reported to have the ability to reverse stress-induced changes [56, 57] and that fluoxetine increases the phosphorylation of MAP-2 [58] that is amongst neuronal microtubule-associated proteins (MAPs) an abundant group of cytoskeletal components.
Phosphorylation (phosphorylation) of MAP-2 in neuronal associated with stress and fluoxetine
8) Confidence 0.67 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.16 Pain Relevance 0.37
Protein phosphorylation of neurofilament proteins, as well as MAP-2 was significantly decreased upon treatment.
Phosphorylation (phosphorylation) of MAP-2
9) Confidence 0.62 Published 1988 Journal Brain Res. Section Abstract Doc Link 3145093 Disease Relevance 0.17 Pain Relevance 0.12
The ischemia-induced rapid elevation of intracellular Ca2+ concentration and subsequent activation of Ca2+-dependent phosphatases (e.g., calcineurin) and proteases (e.g., calpains) can lead to dephosphorylation and proteolytic degradation of MAP2 [18,19].
Phosphorylation (dephosphorylation) of MAP2 associated with ischemia
10) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.61 Pain Relevance 0.16
Moreover, our previous findings have suggested that 5-HT1A reduces ERK activity, which in turn reduces MAP2 phosphorylation and microtubule stability (21).
Phosphorylation (phosphorylation) of MAP2
11) Confidence 0.19 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.19
Thus, we speculate that 5-HT2 receptors might activate ERK, leading to increased phosphorylation of MAP2 and its association with microtubules.
Phosphorylation (phosphorylation) of MAP2
12) Confidence 0.19 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.24
For neurotrophic effects, the phosphorylated neurofilament- and MAP2-expressing neurites could be extended in SK-N-SH cells by the treatment of saponins and Panax notoginseng extracts, suggesting the possible axonal and dendritic formation activity [35].
Phosphorylation (phosphorylated) of MAP2-expressing in SK-N-SH
13) Confidence 0.03 Published 2010 Journal Chin Med Section Body Doc Link PMC2978211 Disease Relevance 0.57 Pain Relevance 0.04

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