INT35391

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Context Info
Confidence 0.27
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.17
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefm) cytoskeleton (Nefm)
Anatomy Link Frequency
nerve 3
cerebral cortex 1
Nefm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 98.68 Very High Very High Very High
cerebral cortex 4 98.32 Very High Very High Very High
vincristine 7 98.04 Very High Very High Very High
allodynia 1 97.36 Very High Very High Very High
Hyperalgesia 5 96.96 Very High Very High Very High
Sciatic nerve 9 93.68 High High
Spinal cord 4 92.72 High High
induced neuropathy 5 79.68 Quite High
peripheral neuropathy 1 59.60 Quite High
Thermal hyperalgesia 1 52.24 Quite High
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Diabetes Mellitus 71 98.94 Very High Very High Very High
Pain 2 98.68 Very High Very High Very High
Congenital Anomalies 2 97.96 Very High Very High Very High
Neuropathic Pain 11 97.36 Very High Very High Very High
Hyperalgesia 6 96.96 Very High Very High Very High
Poisoning 4 94.32 High High
Cancer 4 92.08 High High
Carcinosarcoma 1 90.00 High High
Skin Cancer 1 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein staining revealed a decreased amount of neurofilament protein and immunoblotting demonstrated neurofilament protein cross-linking in these animals.
Negative_regulation (decreased) of neurofilament protein
1) Confidence 0.27 Published 1988 Journal Brain Res. Section Abstract Doc Link 3145093 Disease Relevance 0.17 Pain Relevance 0.11
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Negative_regulation (decreased) of NF-M
2) Confidence 0.27 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
Therefore, we suggest that the axonal degeneration in STZ-induced diabetic rats was reflected by the distorted circularity and decreased NF-H, NF-M, and NF-L in the distal sural nerves of STZ-induced diabetic rats.
Negative_regulation (decreased) of NF-M in nerves associated with diabetes mellitus
3) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 1.00 Pain Relevance 0.18
The levels of neurofilaments (NFs) subunits (NF-L, NF-M and NF-H) in nerve tissues of 200 and 400mg/kg HD rats significantly decreased in both the supernatant and pellet fractions.
Negative_regulation (decreased) of NF-M in nerve
4) Confidence 0.25 Published 2008 Journal Toxicology Section Abstract Doc Link 18177991 Disease Relevance 0.08 Pain Relevance 0.26
We demonstrated that pre-treatment of cerebral cortex slices of young rats with 2.5 mM buffered methylmalonic acid (MMA) is effective in decreasing in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulins.
Negative_regulation (decreasing) of NF-M in cerebral cortex associated with cerebral cortex
5) Confidence 0.22 Published 1997 Journal Brain Res. Section Abstract Doc Link 9296563 Disease Relevance 0 Pain Relevance 0.13
Results showed that the three neurofilament (NF) subunits (NF-L, NF-M, NF-H) in both the pellet and the supernatant fraction decreased significantly (P < 0.01) in the high-dosing group, except for NF-M in the pellet. alpha-tubulin, beta-tubulin, and beta-actin increased significantly in the supernatant (P < 0.01), whereas both alpha-tubulin and beta-tubulin decreased significantly in the pellet (P < 0.01).
Negative_regulation (decreased) of NF-M
6) Confidence 0.14 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17043767 Disease Relevance 0.31 Pain Relevance 0.26
Neurosteroids counteracted vincristine-induced alterations in peripheral nerves including 2',3'-cyclic nucleotide 3'-phosphodiesterase, neurofilament-200 kDa and intraepidermal nerve fiber repression, nerve conduction velocity, and pain transmission abnormalities (allodynia/hyperalgesia).
Negative_regulation (repression) of neurofilament-200 kDa in nerve associated with pain, vincristine, hyperalgesia, allodynia, congenital anomalies and repression
7) Confidence 0.08 Published 2010 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 20431905 Disease Relevance 1.37 Pain Relevance 0.72

General Comments

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