INT35396

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Context Info
Confidence 0.07
First Reported 1981
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.10
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfs) Golgi apparatus (Mthfs) plasma membrane (Mthfs)
ligase activity (Mthfs) cytoplasm (Mthfs)
Mthfs (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 6 99.68 Very High Very High Very High
Inflammation 6 98.64 Very High Very High Very High
cINOD 3 93.76 High High
Arthritis 1 83.04 Quite High
Bioavailability 1 74.28 Quite High
Pain 2 25.00 Low Low
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypersensitivity 5 97.20 Very High Very High Very High
INFLAMMATION 8 91.52 High High
Arthus Reaction 1 84.40 Quite High
Experimental Arthritis 1 83.04 Quite High
Pathologic Neovascularization 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This activity is not associated with inhibition of cyclo-oxygenase.
cyclo-oxygenase Binding (associated) of
1) Confidence 0.07 Published 1981 Journal Agents Actions Section Abstract Doc Link 6456651 Disease Relevance 0.85 Pain Relevance 0.28
Considering that activity of cyclo-oxigenases 1 and 2 is inhibited by sulindac, and that these enzymes are located in the stromal tissue, we propose that the anti-angiogenic effect of these agents may occur via inhibition of both COX isoforms.
cyclo-oxigenases 1 Binding (activity) of
2) Confidence 0.03 Published 2002 Journal Biol. Res. Section Abstract Doc Link 12462986 Disease Relevance 0.25 Pain Relevance 0.17
BW775C was also analgesic, but inhibited cyclo-oxygenase, 5-lipoxygenase and 12-HETE formation.
cyclo-oxygenase Binding (formation) of associated with analgesic
3) Confidence 0.03 Published 1988 Journal J Pharmacol Methods Section Abstract Doc Link 3145369 Disease Relevance 0 Pain Relevance 0.57

General Comments

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