INT353966

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Context Info
Confidence 0.43
First Reported 2011
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.16
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
neurons 4
Pet1 4
Lmx1b (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 112 99.68 Very High Very High Very High
Neurotransmitter 14 96.68 Very High Very High Very High
Dopamine 56 94.24 High High
Locus ceruleus 14 80.80 Quite High
medulla 21 78.32 Quite High
Serotonin 21 75.00 Quite High
Ventral tegmentum 7 72.56 Quite High
Substantia nigra 7 71.48 Quite High
monoamine 14 67.44 Quite High
depression 7 52.56 Quite High
Disease Link Frequency Relevance Heat
Mental Disorders 21 54.64 Quite High
Depression 7 52.56 Quite High
Post-traumatic Stress Disorder 7 51.36 Quite High
Pain 7 31.84 Quite Low
Anxiety Disorder 7 25.28 Quite Low
Body Weight 21 5.00 Very Low Very Low Very Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we took advantage of an inducible Cre-LoxP system to inactivate Lmx1b expression in adult 5-HTergic neurons.
Negative_regulation (inactivate) of Gene_expression (expression) of Lmx1b in neurons
1) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.36
We used an inducible Cre-LoxP system to selectively inactivate Lmx1b expression in the raphe nuclei of adult mice.
Negative_regulation (inactivate) of Gene_expression (expression) of Lmx1b associated with raphe
2) Confidence 0.43 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.22
Loss of Pet1 in the 5-HTergic neurons leads to a decrease of Tph2 expression but no change in Lmx1b expression.
Negative_regulation (decrease) of Gene_expression (expression) of Lmx1b in Pet1
3) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.16 Pain Relevance 0.16
To test this hypothesis, we used a tamoxifen-inducible Cre-LoxP system [13] to selectively inactivate Lmx1b expression in central 5-HTergic neurons of adult mice.
Negative_regulation (inactivate) of Gene_expression (expression) of Lmx1b in neurons
4) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
To test whether deleting Lmx1b decreases the number of 5-HTergic neurons or not, which in turn results in the phenotypes mentioned above, we examined the expression of Aadc and Pet1.
Spec (whether) Negative_regulation (deleting) of Gene_expression (decreases) of Lmx1b in Pet1
5) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Negative_regulation (deleted) of Gene_expression (/) of Lmx1bflox
6) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.18
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Negative_regulation (deleted) of Gene_expression (allele) of Lmx1b
7) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.18

General Comments

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