INT353967

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Context Info
Confidence 0.42
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gata2) nucleus (Gata2) DNA binding (Gata2)
protein complex (Gata2) transcription factor binding (Gata2)
Anatomy Link Frequency
ventricular zone 2
Gata2 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 3 88.08 High High
Pain 1 81.08 Quite High
Serotonin 3 77.84 Quite High
Neurotransmitter 2 77.44 Quite High
Raphe 16 58.48 Quite High
Dopamine 8 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mental Disorders 3 97.76 Very High Very High Very High
Pain 1 81.08 Quite High
Body Weight 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sonic hedgehog secreted from the floor plate triggers the expression of Mash1 and GATA2 in progenitor cells in the ventricular zone of hindbrain [6], and both genes are essential for the development of 5-HTergic neurons [7], [8]. 5-HTergic neurons are classified into two groups based on their anatomical location: a rostral group located in the pons and a caudal group located in the medulla oblongata.
Positive_regulation (triggers) of Gene_expression (expression) of GATA2 in ventricular zone associated with medulla
1) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.18 Pain Relevance 0.23

General Comments

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