INT353976

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Context Info
Confidence 0.42
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 64 83.28 Quite High
medulla 12 73.24 Quite High
Serotonin 12 50.00 Quite Low
Neurotransmitter 8 44.96 Quite Low
Pain 4 26.76 Quite Low
Dopamine 32 24.48 Low Low
Locus ceruleus 8 11.04 Low Low
monoamine 8 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mental Disorders 12 43.44 Quite Low
Pain 4 26.76 Quite Low
Body Weight 12 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As we showed in the present study, the inactivation of Lmx1b in adulthood led to a reduction in central 5-HT levels, probably as a consequence of Tph2 down-regulation.
Negative_regulation (regulation) of Negative_regulation (down) of Tph2
1) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.07
As we showed in the present study, the inactivation of Lmx1b in adulthood led to a reduction in central 5-HT levels, probably as a consequence of Tph2 down-regulation.
Negative_regulation (down) of Negative_regulation (regulation) of Tph2
2) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.07
Our data showed that 5-HT level in Lmx1b iCKO mice was reduced to 60% of control mice probably due to down-regulation of Tph2.
Negative_regulation (reduced) of Negative_regulation (regulation) of Tph2
3) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.10
Our data showed that 5-HT level in Lmx1b iCKO mice was reduced to 60% of control mice probably due to down-regulation of Tph2.
Negative_regulation (down) of Negative_regulation (regulation) of Tph2
4) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.10

General Comments

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