INT353978

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Context Info
Confidence 0.31
First Reported 2011
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
Pet1 3
adult brain 1
Lmx1b (Mus musculus)
Pet1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 16 98.64 Very High Very High Very High
Raphe 32 91.56 High High
Neurotransmitter 4 87.52 High High
monoamine 4 86.56 High High
depression 2 70.56 Quite High
Substantia nigra 2 64.08 Quite High
Ventral tegmentum 2 62.40 Quite High
Locus ceruleus 4 57.76 Quite High
Serotonin 6 50.00 Quite Low
Somatosensory cortex 2 24.32 Low Low
Disease Link Frequency Relevance Heat
Mental Disorders 6 72.64 Quite High
Depression 2 70.56 Quite High
Post-traumatic Stress Disorder 2 69.36 Quite High
Anxiety Disorder 2 43.28 Quite Low
Body Weight 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that Lmx1b and Pet1 act in parallel to regulate central 5-HTergic system, the expression of Pet1 in adult brain is independent of Lmx1b, and Pet1 is not involved in alterations of gene expression in Lmx1b iCKO mice.
Lmx1b Neg (independent) Regulation (independent) of Gene_expression (expression) of Pet1 in Pet1
1) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.21 Pain Relevance 0.15
These results suggest that the overall number of 5-HTergic neurons is not affected by deleting Lmx1b in adulthood, and that Pet1 expression in the adult brain is independent of Lmx1b.


Lmx1b Neg (independent) Regulation (independent) of in Pet1 Gene_expression (expression) of Pet1 in adult brain
2) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.38

General Comments

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