INT354045

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Context Info
Confidence 0.26
First Reported 2011
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1b) plasma membrane (Avpr1b) response to stress (Avpr1b)
signal transducer activity (Avpr1b)
Anatomy Link Frequency
brain 2
ovary 2
Avpr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 4 99.06 Very High Very High Very High
antagonist 34 92.04 High High
antidepressant 2 79.32 Quite High
Pyramidal cell 2 63.44 Quite High
Hippocampus 8 60.16 Quite High
amygdala 2 53.20 Quite High
depression 16 41.52 Quite Low
agonist 18 30.76 Quite Low
medulla 12 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 16 78.36 Quite High
Stress 160 78.00 Quite High
Targeted Disruption 120 62.56 Quite High
Aggression 34 51.04 Quite High
Depression 20 41.52 Quite Low
Affective Disorder 4 9.92 Low Low
Attention Deficit Hyperactivity Disorder 4 5.20 Low Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of various brain regions and peripheral tissues suggests that Avpr1b transcript levels may be too low to be reliably detected by Northern blot analysis and often depends on RT-PCR to detect possible Avpr1b expression (Lolait et al. 1995).
Regulation (depends) of Spec (possible) Gene_expression (expression) of Avpr1b in brain
1) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.05 Pain Relevance 0.09
More recently, other non-peptide antagonists have been described: “p”, a tetrahydroquinoline sulphonamide derivative, with high selectivity for the rat and human Avpr1b (Kis approximately 21 nM and 44 nM, respectively) (Scott et al. 2009), and compounds generated from a series of pyrrole-pyrazinone and pyrazole-pyrazinone derivatives which also appear to show good selectivity and high potency (e.g., compound 11 pIC50 = 8.4) for the human Avpr1b expressed in Chinese hamster ovary cells (Arban et al. 2010)—to our knowledge the effects of these compounds on HPA axis activity or behaviour have not been reported to date.
Regulation (effects) of Gene_expression (expressed) of Avpr1b in ovary associated with antagonist and potency
2) Confidence 0.22 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.49 Pain Relevance 0.27

General Comments

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