INT354045

Context Info Confidence 0.26 First Reported 2011 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.54 Pain Relevance 0.36

signal transduction (Avpr1b) plasma membrane (Avpr1b) response to stress (Avpr1b) signal transducer activity (Avpr1b)

Anatomy Link Frequency brain 2 ovary 2 Avpr1b (Mus musculus)

Pain Link Frequency Relevance Heat Potency 4 99.06 antagonist 34 92.04 antidepressant 2 79.32 Pyramidal cell 2 63.44 Hippocampus 8 60.16 amygdala 2 53.20 depression 16 41.52 agonist 18 30.76 medulla 12 5.00 Catecholamine 6 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 16 78.36 Stress 160 78.00 Targeted Disruption 120 62.56 Aggression 34 51.04 Depression 20 41.52 Affective Disorder 4 9.92 Attention Deficit Hyperactivity Disorder 4 5.20 Sprains And Strains 24 5.00 Obesity 6 5.00 Hypersensitivity 6 5.00

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Anatomy

Negation

Speculation

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Disease term

Analysis of various brain regions and peripheral tissues suggests that Avpr1b transcript levels may be too low to be reliably detected by Northern blot analysis and often depends on RT-PCR to detect possible Avpr1b expression (Lolait et al. 1995).

Regulation (depends) of Spec (possible) Gene_expression (expression) of Avpr1b in brain

1) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.05 Pain Relevance 0.09

More recently, other non-peptide antagonists have been described: “p”, a tetrahydroquinoline sulphonamide derivative, with high selectivity for the rat and human Avpr1b (Kis approximately 21 nM and 44 nM, respectively) (Scott et al. 2009), and compounds generated from a series of pyrrole-pyrazinone and pyrazole-pyrazinone derivatives which also appear to show good selectivity and high potency (e.g., compound 11 pIC50 = 8.4) for the human Avpr1b expressed in Chinese hamster ovary cells (Arban et al. 2010)—to our knowledge the effects of these compounds on HPA axis activity or behaviour have not been reported to date.

Regulation (effects) of Gene_expression (expressed) of Avpr1b in ovary associated with antagonist and potency

2) Confidence 0.22 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.49 Pain Relevance 0.27

General Comments

This test has worked.