INT354046

Context Info Confidence 0.58 First Reported 2011 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 5 Disease Relevance 3.96 Pain Relevance 0.63

signal transduction (Avpr1b) plasma membrane (Avpr1b) response to stress (Avpr1b) signal transducer activity (Avpr1b)

Anatomy Link Frequency pancreas 1 pituitary 1 Avpr1b (Mus musculus)

Pain Link Frequency Relevance Heat depression 40 99.80 Morphine 5 92.08 antagonist 85 90.68 medulla 30 88.56 Catecholamine 15 79.72 Potency 10 64.24 agonist 45 48.12 antidepressant 5 45.44 Hippocampus 20 5.00 ketamine 5 5.00

Disease Link Frequency Relevance Heat Depression 50 99.80 Anxiety Disorder 40 99.50 Stress 400 99.32 Obesity 15 99.04 Targeted Disruption 300 98.40 Aggression 85 98.22 Hypersensitivity 15 87.72 Sprains And Strains 60 84.96 Diabetes Mellitus 5 72.92 Affective Disorder 10 72.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This provides a possible mechanism of physiological Avpr1b gene regulation that may enable different levels of Avpr1b expression in different tissues or species.

Spec (possible) Regulation (regulation) of Avpr1b

1) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.52 Pain Relevance 0.10

The mechanism(s) by which hypothalamic Avp and pituitary Avpr1b responsiveness is maintained during stress adaptation suggests the existence of numerous transcriptional and translational regulatory components involved in PVN and pituitary plasticity that dynamically alter Avp and Avpr1b levels according to demand (Volpi et al. 2004a,b).

Regulation (alter) of Avpr1b in pituitary associated with stress

2) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.78 Pain Relevance 0.06

The behavioural implications of Avp, acting via the Avpr1b, in aggression and stress, and the integral connection between stress, anxiety and depression make the Avpr1b an attractive target for pharmacological intervention.

Regulation (target) of Avpr1b associated with stress, depression, anxiety disorder and aggression

3) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.28 Pain Relevance 0.28

Whether this is due to a lack of Avpr1b influence in the pancreas, white adipose tissue, or both, is unclear.

Regulation (influence) of Avpr1b in pancreas associated with obesity

4) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.60 Pain Relevance 0.07

The apparent flip in control of ACTH release from Crh to Avp that is seen in some repeated stressors in rats (e.g. restraint) has made Avp and the Avpr1b attractive targets for pharmacological intervention in conditions of repeated or chronic stress, although it should be noted that Avp does not play a role in HPA axis responses to all chronic stressors (e.g. chronic morphine injection (Domokos et al. 2008)).

Regulation (targets) of Avpr1b associated with stress and morphine

5) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.79 Pain Relevance 0.12

General Comments

This test has worked.