INT354046

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Context Info
Confidence 0.58
First Reported 2011
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.96
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1b) plasma membrane (Avpr1b) response to stress (Avpr1b)
signal transducer activity (Avpr1b)
Anatomy Link Frequency
pancreas 1
pituitary 1
Avpr1b (Mus musculus)
Pain Link Frequency Relevance Heat
depression 40 99.80 Very High Very High Very High
Morphine 5 92.08 High High
antagonist 85 90.68 High High
medulla 30 88.56 High High
Catecholamine 15 79.72 Quite High
Potency 10 64.24 Quite High
agonist 45 48.12 Quite Low
antidepressant 5 45.44 Quite Low
Hippocampus 20 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 50 99.80 Very High Very High Very High
Anxiety Disorder 40 99.50 Very High Very High Very High
Stress 400 99.32 Very High Very High Very High
Obesity 15 99.04 Very High Very High Very High
Targeted Disruption 300 98.40 Very High Very High Very High
Aggression 85 98.22 Very High Very High Very High
Hypersensitivity 15 87.72 High High
Sprains And Strains 60 84.96 Quite High
Diabetes Mellitus 5 72.92 Quite High
Affective Disorder 10 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This provides a possible mechanism of physiological Avpr1b gene regulation that may enable different levels of Avpr1b expression in different tissues or species.
Spec (possible) Regulation (regulation) of Avpr1b
1) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.52 Pain Relevance 0.10
The mechanism(s) by which hypothalamic Avp and pituitary Avpr1b responsiveness is maintained during stress adaptation suggests the existence of numerous transcriptional and translational regulatory components involved in PVN and pituitary plasticity that dynamically alter Avp and Avpr1b levels according to demand (Volpi et al. 2004a,b).
Regulation (alter) of Avpr1b in pituitary associated with stress
2) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.78 Pain Relevance 0.06
The behavioural implications of Avp, acting via the Avpr1b, in aggression and stress, and the integral connection between stress, anxiety and depression make the Avpr1b an attractive target for pharmacological intervention.
Regulation (target) of Avpr1b associated with stress, depression, anxiety disorder and aggression
3) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.28 Pain Relevance 0.28
Whether this is due to a lack of Avpr1b influence in the pancreas, white adipose tissue, or both, is unclear.
Regulation (influence) of Avpr1b in pancreas associated with obesity
4) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.60 Pain Relevance 0.07
The apparent flip in control of ACTH release from Crh to Avp that is seen in some repeated stressors in rats (e.g. restraint) has made Avp and the Avpr1b attractive targets for pharmacological intervention in conditions of repeated or chronic stress, although it should be noted that Avp does not play a role in HPA axis responses to all chronic stressors (e.g. chronic morphine injection (Domokos et al. 2008)).
Regulation (targets) of Avpr1b associated with stress and morphine
5) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.79 Pain Relevance 0.12

General Comments

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