INT35406

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Context Info
Confidence 0.81
First Reported 1988
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 94
Total Number 94
Disease Relevance 64.63
Pain Relevance 31.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
peritoneal macrophages 6
macrophages 5
neutrophil 4
liver 3
mast cells 3
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 480 100.00 Very High Very High Very High
cytokine 302 100.00 Very High Very High Very High
chemokine 90 100.00 Very High Very High Very High
Inflammatory response 61 100.00 Very High Very High Very High
Inflammatory mediators 23 100.00 Very High Very High Very High
anesthesia 12 99.98 Very High Very High Very High
Infliximab 7 99.76 Very High Very High Very High
vincristine 12 99.70 Very High Very High Very High
bradykinin 7 99.46 Very High Very High Very High
Peripheral nerve injury 4 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 578 100.00 Very High Very High Very High
Cancer 130 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 108 100.00 Very High Very High Very High
Necrosis 86 100.00 Very High Very High Very High
Disease 211 99.84 Very High Very High Very High
Apoptosis 192 99.76 Very High Very High Very High
Obesity 133 99.68 Very High Very High Very High
Injury 223 99.48 Very High Very High Very High
Nervous System Injury 6 99.44 Very High Very High Very High
Dehydration 14 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to explore the antinociceptive effect of lycopene and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.
Localization (release) of TNF-alpha associated with necrosis, diabetes mellitus, cancer and antinociceptive
1) Confidence 0.81 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18055235 Disease Relevance 1.42 Pain Relevance 0.65
Lycopene also inhibited the TNF-alpha and NO release in a dose dependent manner.
Localization (release) of TNF-alpha
2) Confidence 0.81 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18055235 Disease Relevance 1.29 Pain Relevance 0.73
These results indicate an antinociceptive activity of curcumin possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.
Localization (release) of TNF-alpha associated with diabetes mellitus, neuropathic pain and antinociceptive
3) Confidence 0.81 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16584726 Disease Relevance 1.33 Pain Relevance 0.70
These results indicate an antinociceptive activity of lycopene possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.
Localization (release) of TNF-alpha associated with diabetes mellitus, neuropathic pain and antinociceptive
4) Confidence 0.81 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18055235 Disease Relevance 1.39 Pain Relevance 0.71
Curcumin also inhibited the TNF-alpha and NO release in a dose dependent manner.
Localization (release) of TNF-alpha
5) Confidence 0.81 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16584726 Disease Relevance 1.27 Pain Relevance 0.72
The aim of the present study was to explore the antinociceptive effect of curcumin and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.
Localization (release) of TNF-alpha associated with necrosis, diabetes mellitus, cancer and antinociceptive
6) Confidence 0.81 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16584726 Disease Relevance 1.41 Pain Relevance 0.65
The aim of the present study was to explore the antinociceptive effect of resveratrol on diabetic neuropathic pain and to examine its effect on serum tumour necrosis factor-alpha (TNF-alpha) and whole brain nitric oxide (NO) release.
Localization (release) of TNF-alpha in brain associated with necrosis, cancer, diabetes mellitus, neuropathic pain and antinociceptive
7) Confidence 0.81 Published 2007 Journal Fundam Clin Pharmacol Section Abstract Doc Link 17227449 Disease Relevance 1.50 Pain Relevance 0.82
Maximum release of TNF-alpha was seen at a concentration of 10(-12) M of morphine.
Localization (release) of TNF-alpha
8) Confidence 0.80 Published 2000 Journal Inflammation Section Body Doc Link 10921509 Disease Relevance 0.13 Pain Relevance 0
Additionally, LPS elicited a robust nitric oxide (NO) and TNF-alpha secretion whereas HD was practically ineffective.
Localization (secretion) of TNF-alpha
9) Confidence 0.80 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20519843 Disease Relevance 0.43 Pain Relevance 0.29
Pretreatment of cultures with naloxone (1 microM) followed by treatment with lipopolysaccharide significantly inhibited the lipopolysaccharide-induced production of nitric oxide and the release of tumor necrosis factor-alpha, and significantly reduced the lipopolysaccharide-induced damage to neurons.
Localization (release) of tumor necrosis factor-alpha in neurons associated with necrosis, cancer and narcan
10) Confidence 0.79 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842020 Disease Relevance 0.41 Pain Relevance 0.52
This suggestion is supported by the following observations: (a) pretreatment of the peritoneal cavities with antisera against these cytokines reduced the nociceptive responses induced by these stimuli; (b) peritoneal cells harvested from cavities injected with zymosan or acetic acid released both interleukin 1beta and TNF-alpha; (c) although individual injection of TNF-alpha, interleukin 1beta or interleukin 8 did not induce the nociceptive effect, intraperitoneal injection of a mixture of these three recombinant cytokines caused a significant nociceptive writhing response.
Localization (released) of TNF-alpha in cavities associated with nociception and cytokine
11) Confidence 0.79 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.94 Pain Relevance 0.09
In conclusion, our results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleukin 8 by resident peritoneal macrophages and mast cells.
Localization (release) of TNF-alpha in peritoneal macrophages associated with nociception
12) Confidence 0.79 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.70 Pain Relevance 0.09
These cells modulate the nociceptive response induced by zymosan and acetic acid via release of tumour necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 8.
Localization (release) of TNF-alpha associated with nociception, necrosis and cancer
13) Confidence 0.79 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.89 Pain Relevance 0.07
These data demonstrate how microglial pro-inflammatory secretions including TNFalpha can acutely facilitate glutamate-dependent neuron death.
Localization (secretions) of TNFalpha in neuron associated with glutamate, inflammation and death
14) Confidence 0.79 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241124 Disease Relevance 0.81 Pain Relevance 0.63
Hyperalgesic responses to intraplantar (i.pl.) injections of carrageenin or bradykinin, which act by stimulating TNF-alpha release, but not responses to TNF-alpha or prostaglandin E(2), were inhibited in a dose-dependent manner by pretreatment of the animals with thalidomide.
Localization (release) of TNF-alpha associated with hyperalgesia and bradykinin
15) Confidence 0.78 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10720640 Disease Relevance 0.68 Pain Relevance 0.39
SUMMARY OF BACKGROUND DATA.: TNF-alpha is a primary mediator of the inflammatory response and is primarily synthesized and released in the nervous system by macrophages and Schwann cells following peripheral nerve injury.
Localization (released) of TNF-alpha in peripheral nerve associated with inflammatory response, nervous system injury and peripheral nerve injury
16) Confidence 0.78 Published 2004 Journal Spine Section Abstract Doc Link 15131433 Disease Relevance 0.65 Pain Relevance 0.36
TNF-alpha is also released from astrocytes and microglia in the central nervous system, where it plays a crucial role in the pathophysiology of injury.
Localization (released) of TNF-alpha in central nervous system associated with injury and central nervous system
17) Confidence 0.78 Published 2004 Journal Spine Section Abstract Doc Link 15131433 Disease Relevance 0.71 Pain Relevance 0.36
UVA1 effects on DNA repair, cell-mediated immunosuppression, tumor necrosis factor alpha release, and apoptosis contrast markedly with those of ultraviolet B (UVB, 280-320 nm) radiation and afford a possible basis for the salutary action of this modality of treatment.
Localization (release) of tumor necrosis factor associated with necrosis, cancer and apoptosis
18) Confidence 0.78 Published 1999 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 10537014 Disease Relevance 1.12 Pain Relevance 0.09
Mitogen-stimulated splenocytes had a lower production of interferon-gamma as well as an increase in the secretion of tumor necrosis factor-alpha.
Localization (secretion) of tumor necrosis factor associated with necrosis and cancer
19) Confidence 0.78 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253541 Disease Relevance 1.21 Pain Relevance 0.69
Side effects of treatment have included muscle pain and joint aches, a transient decrease in platelets, and the release of tumor necrosis factor alpha (TNF alpha) and IL-6 into the blood stream.
Localization (release) of tumor necrosis factor in blood associated with pain, necrosis, cancer and myalgia
20) Confidence 0.78 Published 1996 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 8529289 Disease Relevance 1.00 Pain Relevance 0.14

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