INT35407

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 7.74
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
Anatomy Link Frequency
blood 2
vessels 1
bands 1
lung 1
gut 1
C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 23 99.84 Very High Very High Very High
imagery 30 99.82 Very High Very High Very High
tissue acidosis 2 99.30 Very High Very High Very High
anesthesia 33 99.22 Very High Very High Very High
rheumatoid arthritis 7 99.08 Very High Very High Very High
c fibre 43 98.72 Very High Very High Very High
Clonidine 7 98.72 Very High Very High Very High
cva 38 98.48 Very High Very High Very High
analgesia 6 95.52 Very High Very High Very High
endometriosis 12 90.20 High High
Disease Link Frequency Relevance Heat
Cough 94 100.00 Very High Very High Very High
Low Back Pain 23 99.84 Very High Very High Very High
Graft Vs Host Disease 6 99.62 Very High Very High Very High
Heart Rate Under Development 3 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 116 99.48 Very High Very High Very High
Sleep Disorders 65 99.36 Very High Very High Very High
Acidosis 2 99.30 Very High Very High Very High
Rheumatoid Arthritis 7 99.08 Very High Very High Very High
Hemorrhage 23 98.48 Very High Very High Very High
Pathologic Constriction 9 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3. a plateau phase when the vasodilation has already reached its maximum, characterized by an almost constant level of O2Hb and a progressive increase of the CO2Hb level.
Positive_regulation (increase) of CO2Hb associated with increased venous pressure under development
1) Confidence 0.69 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.16 Pain Relevance 0
An initial increase in the CO2Hb concentration is rapidly compensated by a steep increase in the O2Hb concentration.
Positive_regulation (increase) of CO2Hb
2) Confidence 0.69 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.09 Pain Relevance 0
We have shown that the baseline measurement of C2 was highly consistent between the methods used despite considerable differences in challenge protocols and devices.
Positive_regulation (measurement) of C2 associated with cough
3) Confidence 0.50 Published 2010 Journal Cough Section Body Doc Link PMC2925329 Disease Relevance 0.74 Pain Relevance 0.13
The mean motion angle at the adjacent level to the fixed segment did not change postoperatively, but the mean motion between C-1 and C-2 increased and slight atlantoaxial subluxation occurred postoperatively in five patients.
Positive_regulation (increased) of C-2
4) Confidence 0.49 Published 2002 Journal J. Neurosurg. Section Body Doc Link 12120637 Disease Relevance 0 Pain Relevance 0
The incidence of shivering was significantly increased in group M compared to group C 2 and C 4 .
Positive_regulation (increased) of C 2
5) Confidence 0.49 Published 2009 Journal Biosci Trends Section Abstract Doc Link 20103833 Disease Relevance 0.40 Pain Relevance 0.77
When the vasodilation has reached its maximum, there's a plateau region in which the O2Hb concentration remains almost constant, while the CO2Hb concentration starts increasing; afterwards, BH ends.
Positive_regulation (increasing) of CO2Hb associated with increased venous pressure under development
6) Confidence 0.46 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.10 Pain Relevance 0
It can be noticed how O2Hb starts increasing only at the end of the BH phase, whereas CO2Hb rapidly increases during all the apnea and is never compensated.
Positive_regulation (increases) of CO2Hb associated with sleep disorders
7) Confidence 0.43 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.10 Pain Relevance 0
Figure 2 reports an example of the changes occurring in the O2Hb (red line) and CO2Hb (blue line) concentrations during BH of a single healthy subject.
Positive_regulation (occurring) of CO2Hb
8) Confidence 0.43 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.15 Pain Relevance 0.04
Guinea pigs were fitted with a carotid cannula under anesthesia and used 2 days later for exposure to increasing CO2 concentrations to evaluate their ventilatory response (tidal volume and respiratory frequency) while blood samples were taken for measurement of O2, CO2, and pH.
Positive_regulation (increasing) of CO2 in blood associated with anesthesia
9) Confidence 0.40 Published 1988 Journal Fundam Appl Toxicol Section Abstract Doc Link 3146519 Disease Relevance 0 Pain Relevance 0.10
It is known that baroreceptors react to an increased partial pressure of CO2 by inducing vasodilatation in the resistance vessels; hence, the mean CBFV increases and the resistance of the vessels drops [6].
Spec (partial) Positive_regulation (increased) of CO2 in vessels associated with increased venous pressure under development
10) Confidence 0.40 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.20 Pain Relevance 0.08
In Case 2, additional instrument to the occipital was performed to stabilize the C2 using a U-shaped cervical rod.
Positive_regulation (stabilize) of C2
11) Confidence 0.38 Published 2004 Journal Surg Neurol Section Body Doc Link 15165782 Disease Relevance 0 Pain Relevance 0
Another mechanism may be related to increased levels of inspired CO2 in commercial flights.
Positive_regulation (increased) of CO2
12) Confidence 0.29 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2880141 Disease Relevance 1.22 Pain Relevance 0.05
In this case the surface patch generated as a solution to the fourth order PDE contains the boundary curves c1 and c4 whilst it does not necessarily contain the curves c2 and c3.
Neg (not) Positive_regulation (curves) of c2
13) Confidence 0.25 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0 Pain Relevance 0
In patients with stenoses a proportion have an increased difference between their arterial and intragastric P CO2 (an elevated PCO2 gap) at rest, suggesting poor perfusion.
Positive_regulation (elevated) of P CO2 associated with pathologic constriction
14) Confidence 0.22 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.94 Pain Relevance 0.05
The two person game introduced above provides not only the ideal ground to introduce such a diversity of contributions, but also an intuitive coupling between game dynamics and social embedding: The first (second) individual contributes a cost c1 (c2) if playing C and nothing otherwise.
Positive_regulation (contributes) of c2
15) Confidence 0.19 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2782104 Disease Relevance 0 Pain Relevance 0
It has been suggested that in some cases the Haldane effect may be responsible for increased CO2 levels in situations of increased oxygen extraction in the absence of decreased perfusion [21].
Positive_regulation (increased) of CO2
16) Confidence 0.14 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.29 Pain Relevance 0
The assumption that intraluminal gut CO2 is elevated when local perfusion is compromised is based on the concept that in situations where gastrointestinal perfusion is reduced oxygen delivery falls below a critical level, resulting in anaerobic cellular metabolism that leads to local lactic acidosis and generation of CO2.
Positive_regulation (elevated) of CO2 in gut associated with lactic acidosis
17) Confidence 0.14 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.15 Pain Relevance 0
Thus C1 frequencies were increased in RA and kidney graft rejection, whereas those of C2 were increased in AS, and kidney rejection.
Positive_regulation (increased) of C2 in kidney associated with spinal inflammation, rheumatoid arthritis and graft vs host disease
18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 1.19 Pain Relevance 0.49
There was a trend for expression of the proteasome C2 subunit protein to fall at insulin concentrations of 30–72 mU/l, and this fall became significant at an insulin concentration of 167 mU/l, when its expression declined by ?
Positive_regulation (proteasome) of C2
19) Confidence 0.12 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Increasing N2-Flag concentrations resulted in increasing C2 interaction signals with a maximum at the bead capacity of approximately 10 nM bound protein.
Positive_regulation (increasing) of C2
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0

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