INT354071

Context Info Confidence 0.12 First Reported 2011 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.03

extracellular region (Pomc, Cort) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)

Pomc (Mus musculus) Cort (Mus musculus)

Pain Link Frequency Relevance Heat medulla 6 61.84 Serotonin 1 24.20 antagonist 17 5.00 agonist 9 5.00 depression 8 5.00 Hippocampus 4 5.00 Catecholamine 3 5.00 Potency 2 5.00 ketamine 1 5.00 Morphine 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 60 98.42 Stress 80 97.74 Hypersensitivity 3 44.32 Aggression 17 5.00 Sprains And Strains 12 5.00 Depression 10 5.00 Anxiety Disorder 8 5.00 Obesity 3 5.00 Hypoglycemia 3 5.00 Attention Deficit Hyperactivity Disorder 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Where stress-induced ACTH release in Avpr1b KO mice is not always followed by a proportional CORT attenuation, suggests that CORT may be released independently of ACTH in some circumstances.

ACTH Neg (independently) Positive_regulation (independently) of Localization (released) of CORT associated with targeted disruption and stress

1) Confidence 0.12 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

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